Activated microglial cells synthesize and secrete AGE-albumin.
- Author:
Kyunghee BYUN
1
;
Enkhjaigal BAYARSAIKHAN
;
Daesik KIM
;
Myeongjoo SON
;
Junhee HONG
;
Goo Bo JEONG
;
Sun Ha PAEK
;
Moo Ho WON
;
Bonghee LEE
Author Information
- Publication Type:Original Article
- Keywords: Microglia; AGE albumin; Cell death
- MeSH: Alzheimer Disease; Brain; Cell Death; Glycosylation End Products, Advanced; Humans; Microglia; Neurodegenerative Diseases; Neurons; Parkinson Disease
- From:Anatomy & Cell Biology 2012;45(1):47-52
- CountryRepublic of Korea
- Language:English
- Abstract: A holy grail of curing neurodegenerative diseases is to identify the main causes and mechanisms underlying neuronal death. Many studies have sought to identify these targets in a wide variety of ways, but a more important task is to identify critical molecular targets and their origins. Potential molecular targets include advanced glycation end products (AGEs) that can promote neuronal cell death, thereby contributing to neurodegenerative disorders such as Alzheimer disease or Parkinson disease. In this study, we showed that AGE-albumin (glycated albumin) is synthesized in microglial cells and secreted in the human brain. Our results provide new insight into which microglial cells can promote the receptor for AGE-mediated neuronal cell death, eventually leading to neurodegenerative diseases.
