Anti-sepsis effect and mechanism of Apocynum leavesbased on network pharmacology
- VernacularTitle:基于网络药理学的罗布麻叶抗败血症作用及其机制研究
- Author:
Yuanshuo OUYANG
1
,
2
,
3
,
4
;
Yanming WANG
1
,
2
,
3
,
4
;
Xuqing QIN
1
,
2
,
3
,
4
;
Han JIANG
1
,
2
,
3
,
5
;
Luqian LIU
1
,
2
,
3
,
5
;
Wenjun HE
1
,
2
,
3
,
5
;
Xinzhi LI
1
,
2
,
3
,
5
;
Ketao MA
1
,
2
,
3
,
4
Author Information
- Publication Type:Journal Article
- Keywords: Apocynum venetum leaf; sepsis; network pharmacology; target prediction; mechanism of action
- From: Journal of Xi'an Jiaotong University(Medical Sciences) 2021;42(3):484-490
- CountryChina
- Language:Chinese
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Abstract:
【Objective】 To study the mechanism of Apocynum leaves in the treatment of sepsis by network pharmacology method in order to explore the multi-dimensional research method of Xinjiang ethnic medicine treatment of infectious diseases and provide scientific theoretical basis for clinical medication. 【Methods】 TCMSP and literature collection were used to screen the main active components of Apocynum venetum leaf, and target prediction analysis was conducted by SwissTarget Prediction database. We used Genecards database to screen relevant targets for sepsis, used Omicshare to calculate Venn figure of the intersection targets, constructed the protein-protein interaction network diagram in the STRING database, used Ensembl for name conversion of protein targets, then entered Omicshare server for Go function and KEGG pathway enrichment of dynamic analysis. Last we used Cytoscape3.6.0 software to construct "Apocynum venetum leaf-the active ingredients-targets-Go-KEGG-sepsis" network to explore the mechanism of action of Apocynum’s resistance to sepsis. 【Results】 Kaferol, luteolin, proanthocyanidin B
1 and phytosterol in Apocynum venetum leaves may treat sepsis by controlling signal transduction, regulating hormone level and anti-infection through predictive biological targets such as Akt1, VEGFA, MAPK3, EGFR, Src and PTGS2. They can play an important role through VEGF, EGFR, erbB, HIF-1, RAS and other enrichment pathways. 【Conclusion】 The active components of Apocynum venetum leaves can fight against sepsis through multiple targets and multiple pathways.
