The diagnostic value of changes in peripheral blood cell ratioin children with infectious mononucleosis

Mei LÜ; Jieying Wang; Daqing Sun; Liyun Fang; Yang Yang; Yonghui Yang

Return

The diagnostic value of changes in peripheral blood cell ratioin children with infectious mononucleosis

VernacularTitle:外周血细胞比值变化在儿童传染性单核细胞增多症中的诊断价值
Author: Mei LÜ ¹ ; Jieying WANG ² ; Daqing SUN ¹ ; Liyun FANG ¹ ; Yang YANG ¹ ; Yonghui YANG ¹
Author Information

1. Department of Pediatrics, The Affiliated Hospital of Northwest University/Xi’an Third Hospital, Xi’an 710082
2. Department of Pediatrics, Shaanxi Provincial People’s Hospital, Xi’an 710068, China
Publication Type:Journal Article
Keywords: neutrophil-monocyte ratio; lymphocyte to monocyte ratio; infectious mononucleosis; child
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2021;42(3):460-462,483
CountryChina
Language:Chinese
Abstract: 【Objective】 To investigate the diagnostic value of neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte (MLR), and lymphocyte (LYM) count in children with infectious mononucleosis (IM). 【Methods】 Clinical and laboratory data of 134 IM children hospitalized between September 2017 and March 2020 were collected. A total of 60 healthy children during the same period were selected as the control group. The subjects’ NLR, MLR, and LYM were calculated according to the results of peripheral blood. The values of NLR, MLR, and LYM in diagnosing and predicting IM were analyzed with ROC. 【Results】 The MLR and LYM values of IM children were significantly higher than those of the control group (P<0.01), while the NLR values of the two groups were not statistically significant (P>0.05). ROC results showed that the area under the ROC curve (AUC) of NLR was 0.397, AUC of MLR was 0.648, and LYM's AUC was 0.680. The ROC curve AUC of MLR+LYM was 0.878, the optimal threshold was 0.59, the sensitivity was 82.09%, and the specificity was 85.00%. 【Conclusion】 MLR and LYM are independent biomarkers for the prediction of IM in children.