The expression of BMP8A in papillary thyroid carcinoma and its correlation with cervical lymph node metastasis
- VernacularTitle:甲状腺乳头状癌的BMP8A表达及其与颈部淋巴结转移的相关性
- Author:
Xueyu ZENG
1
;
Zhu CHEN
1
;
Min MAO
1
;
Zhibai CHEN
1
;
Chunyu CHEN
1
;
Wenlong CAO
1
;
Jiehua LI
1
Author Information
- Publication Type:Journal Article
- Keywords: bone morphogenetic protein 8A; papillary thyroid carcinoma; cervical lymph node metastasis
- From: Journal of Xi'an Jiaotong University(Medical Sciences) 2021;42(3):443-447,452
- CountryChina
- Language:Chinese
- Abstract: 【Objective】 To investigate the expression of BMP8A in papillary thyroid carcinoma (PTC) and the relationship between its expression level and clinicopathological features of PTC patients. 【Methods】 Based on TCGA and GEO databases, we analyzed and screened BMP8A, one differentially expressed gene related to PTC. From April 2019 to October 2019, 35 cases of thyroid papillary carcinoma and the tumor-adjacent tissues were collected from the Department of Gastrointestinal Gland Surgery, the First Affiliated Hospital of Guangxi Medical University. Real-time PCR was used to detect the expression of BMP8A in PTC and tumor-adjacent tissues, and the relationship between different expression levels and clinicopathological features of the patients was analyzed and compared. Then, we used Western blotting for verification. 【Results】 Both Real-time PCR and Western blotting analyses proved that the expression of BMP8A in PTC was significantly lower than that in the tumor-adjacent tissues (P<0.05), and the expression of BMP8A was also significantly decreased in PTC tissues with cervical lymph node metastasis compared with those without metastasis(P<0.05). 【Conclusion】 BMP8A has a low expression in papillary thyroid carcinoma, and its expression level is related to cervical lymph node metastasis. BMP8A may be a suppressor gene of PTC. This may provide a new direction for further exploring the mechanism of cervical lymph node metastasis in PTC and preventing recurrence after surgery.
