Association of genetic variants in renalase with blood pressure responses to salt and potassium intake

Yang Wang; Yue Sun; Guilin HU; Ting Zou; Xiaoyu Zhang; Mingfei DU; Haowei Zhou; Hao Jia; Dan Wang; Jie Zhang; Chen Chen; Jiawen HU; Qiong MA; Yue Yuan; Yueyuan Liao; Keke Wang; Yu Yan; Xi Zhang; Zejiaxin Niu; Yongjuan Guan; Ruichen Yan; Ke Gao; Min LI; Jianjun MU

Return

Association of genetic variants in renalase with blood pressure responses to salt and potassium intake

VernacularTitle:肾胺酶基因多态性与血压钠钾反应性的相关性分析
Author: Yang WANG ¹ ; Yue SUN ¹ ; Guilin HU ¹ ; Ting ZOU ¹ ; Xiaoyu ZHANG ¹ ; Mingfei DU ¹ ; Haowei ZHOU ¹ ; Hao JIA ¹ ; Dan WANG ¹ ; Jie ZHANG ² ; Chen CHEN ¹ ; Jiawen HU ³ ; Qiong MA ¹ ; Yue YUAN ¹ ; Yueyuan LIAO ¹ ; Keke WANG ¹ ; Yu YAN ¹ ; Xi ZHANG ¹ ; Zejiaxin NIU ¹ ; Yongjuan GUAN ⁴ ; Ruichen YAN ¹ ; Ke GAO ¹ ; Min LI ¹ ; Jianjun MU ¹
Author Information

1. Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061
2. Department of Cardiology, Xi’an No.4 Hospital, Xi’an 710004
3. Department of Cardiovascular Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061
4. Department of Rheumatology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
Publication Type:Journal Article
Keywords: renalase; genetic polymorphism; blood pressure; salt
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2021;42(3):392-397
CountryChina
Language:Chinese
Abstract: 【Objective】 Based on our previously established salt-sensitive hypertension cohort, we conducted chronic salt loading and potassium supplementation interventions, aiming to examine the association between genetic variants in renalase and blood pressure (BP) responses to dietary interventions of salt and potassium intake. 【Methods】 In 2004, 514 subjects from 126 families were recruited in Shaanxi Province to establish the salt-sensitive hypertension study cohort. Among them, 334 non-parent subjects were selected and sequentially maintained on a low-salt diet for 7 days, then a high-salt diet for 7 days and a high-salt diet with potassium supplementation for another 7 days. Ten single nucleotide polymorphisms (SNPs) in the renalase gene were genotyped on the MassARRAY platform. 【Results】 SNP rs2576178 of the renalasegene was significantly associated with systolic BP (SBP) and mean arterial pressure (MAP) responses to low-salt intervention (SBP: β=-2.730, P<0.05; MAP: β=-1.718, P<0.05). In addition, SNP rs12356177 was significantly associated with diastolic BP response to low-salt diet (β=-1.608, P<0.05). However, we did not find any association for the renalase SNPs with BP response to high-salt diet with potassium supplementation reached nominal statistical significance. 【Conclusion】 Genetic variants in renalase gene are significantly associated with BP response to low-salt diet, suggesting that renalase may be mechanistically involved in BP salt-sensitivity.