Comparison of oxycodone with sufentanil in transition analgesia after radical surgery of cervical cancer

Shajie Dang; Wenbo Wei; Wenbin Zeng; Wenhui Zhao; Jun Chen

Return

Comparison of oxycodone with sufentanil in transition analgesia after radical surgery of cervical cancer

VernacularTitle:羟考酮与舒芬太尼对宫颈癌根治术镇痛衔接效果的临床观察
Author: Shajie DANG ^{1
,

2} ; Wenbo WEI ^{3
,

4} ; Wenbin ZENG ¹ ; Wenhui ZHAO ¹ ; Jun CHEN ¹
Author Information

1. Department of Anesthesia, Shaanxi Provincial Cancer Hospital, Xi’an Jiaotong University, Xi’an 710061
2. The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049
3. The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049
4. Department of Orthopedics, Shaanxi Provincial people’s Hospital, Xi’an Jiaotong University, Xi’an 710068, China
Publication Type:Journal Article
Keywords: oxycodone; sufentanil; radical surgery of cervical cancer; transition analgesia
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2021;42(4):592-596
CountryChina
Language:Chinese
Abstract: 【Objective】 To compare the efficacy and safety of oxycodone and sufentanil in transition analgesia after radical surgery of cervical cancer under general anesthesia. 【Methods】 A randomized, double-blind study was conducted. We randomly divided 68 patients on radical surgery of cervical cancer under general anesthesia into two groups: Group S (sufentanil in transition analgesia) (n=35) and Group O (oxycodone in transition analgesia) (n=33). Patients in Group S received sufentanil (0.1 μg/kg for endoscopy procedures or 0.15 μg/kg for laparotomy procedures), whereas patients in Group O received oxycodone (0.1 mg/kg for endoscopy procedures or 0.15 mg/kg for laparotomy procedures) 30 min before the end of operation as transition analgesia. We recorded the time of consciousness recovery and extubation, RSS restlessness score, the number of cough times, Ramsay score, Numerical Rating Scale (NRS) at rest in extubation immediately (T0), 30 min after extubation (T1), 1 h after extubation (T2), 2 h after extubation (T3), 4 h after extubation (T4), 12 h after surgery (T5), 24 h after surgery (T6), and the incidence of adverse complications within 24 h after operation. 【Results】 Compared with those in Group S, patients in Group O showed shorter time of consciousness recovery (4.28±3.35 vs. 5.53±2.25, P=0.027), shorter time of extubation (5.92±3.67 vs. 8.09±2.49, P=0.001), lower RSS restlessness score (0.38±0.49 vs. 0.83±0.63, P<0.001), smaller number of cough times (0.96±0.78 vs. 1.34±0.93, P=0.026), lower Ramsay score (2.3±0.58 vs. 2.63±0.85, P=0.017), and lower NRS score at rest in T3 and T4 (2.64±0.63 vs. 3.14±0.66; 2.86±0.81 vs. 3.69±0.75) (P<0.001). The incidence of nausea and vomiting was lower in Group O than in Group S (9.09% vs. 20%; 3.03% vs. 11.43%). 【Conclusion】 Both oxycodone and sufentanil provide adequate pain relief in transitional analgesia after radical surgery of cervical cancer under general anesthesia. However, oxycodone shows longer analgesia, faster recovery, and a lower incidence of side effects than sufentanil.