Relationship between clinical phenotype and autoantibodies in systemic sclerosis

Qianyun XU; Jing Zhang; Nan HU; Yanhua Wang; Dan PU; Xiaohong LÜ; Zhiming Hao; Lan HE

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Relationship between clinical phenotype and autoantibodies in systemic sclerosis

VernacularTitle:系统性硬化症临床表型与自身抗体相关性研究
Author: Qianyun XU ¹ ; Jing ZHANG ¹ ; Nan HU ¹ ; Yanhua WANG ¹ ; Dan PU ¹ ; Xiaohong LÜ ¹ ; Zhiming HAO ¹ ; Lan HE ¹
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1. Department of Rheumatology and Immunology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
Publication Type:Journal Article
Keywords: systemic sclerosis; autoantibody; anti-CENP-B antibody; anti-Scl-70 antibody
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2021;42(4):585-591
CountryChina
Language:Chinese
Abstract: 【Objective】 To detect autoantibodies in Chinese systemic sclerosis (SSc) patients and analyze the relationship between clinical phenotype and autoantibodies in SSc. 【Methods】 We sequentially included 93 SSc patients. Their general information and clinical data were gathered. The differences in clinical characteristics among autoantibody negative and positive groups were analyzed statistically. 【Results】 Anti-nuclear antibodies were detected in 82 (88.2%) SSc patients. The positive rate of autoantibodies was detected in 26 cases (28.0%) of anti-Scl-70 antibody, 24 cases (25.8%) of anti-SSA/Ro-52 antibody, 19 cases (20.4%) of anti-U1-snRNP antibody, and 16 cases (17.2%) in anti-CENP-B antibody, respectively. The patients with positive anti-SSA/Ro-52 antibody had a significantly higher morbidity rate of pulmonary arterial hypertension (P=0.016). Patients with anti-Scl-70 antibody showed a higher incidence rate of digital tip ulcers or gangrene (P=0.004) and cardiac damage (P=0.014). The patients with anti-U1-snRNP antibody had a higher prevalence of pulmonary arterial hypertension (P=0.047) and Raynaud’s phenomenon (P=0.019), and showed an increased trend in the occurrence of interstitial lung disease (P=0.058). Those with anti-CENP-B antibody had a lower IgG level (P=0.049) and higher ALP (P=0.010) and γ-GT (P=0.003). The incidence of autoimmune liver disease was increased in anti-CENP-B positive patients (P=0.001). 【Conclusion】 Different autoantibodies in SSc are associated with clinical phenotype, and may contribute to the diagnosis, evaluation, and prognostic judgment of the disease.