The research progress and prospect of anti-inflammatory antibacterial hydrogel applied to chronic wounds in diabetes

Yixuan LI; Xu Jiang; Zitong Qin; Hui LI; Xing Liu; Yudi Wang; Xiaofei Liu

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The research progress and prospect of anti-inflammatory antibacterial hydrogel applied to chronic wounds in diabetes

VernacularTitle:抗炎抗菌水凝胶应用于糖尿病慢性伤口的研究进展与展望
Author: Yixuan LI ^{1
,

2} ; Xu JIANG ^{1
,

2} ; Zitong QIN ^{1
,

2} ; Hui LI ^{1
,

2} ; Xing LIU ^{1
,

2} ; Yudi WANG ^{1
,

2} ; Xiaofei LIU ¹
Author Information

1. Institute of Regenerative and Reconstrucitve Medicine, Med-X Institute, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061
2. Xi’an Jiaotong University Health Science Center, Xi’an 710061, China
Publication Type:Journal Article
Keywords: hydrogel; anti-inflammatory; antibacterial; diabetes; chronic wound
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2022;43(6):943-951
CountryChina
Language:Chinese
Abstract: Chronic wounds in diabetes mellitus is a common complication of diabetes mellitus with complex pathogenesis and long recovery time. At present, there are many kinds of dressings for chronic wounds in diabetes, among which synthetic dressings have obvious therapeutic advantages. As an emerging biomaterial, hydrogel has obvious advantages over traditional dressings in terms of water absorption, air permeability, biocompatibility, drug loading ability, and continuous controlled drug release, and has attracted much attention in the repair of chronic wounds in diabetes mellitus. Common hydrogels have anti-inflammatory, antibacterial, antioxidant, tissue-promoting, and hypoglycemic effects. This paper systematically summarizes the progress in research on anti-inflammatory and antibacterial hydrogels in chronic diabetic wounds. Among them, according to different anti-inflammatory and antibacterial mechanisms and materials, common anti-inflammatory hydrogels can be divided into hydrogels loaded with anti-inflammatory drugs, hydrogels based on anti-inflammatory materials, and hydrogels loaded with biological components. Hydrogels can be classified into antibiotic-loaded hydrogels, antibacterial material-based hydrogels, and inorganic nanoparticles-loaded hydrogels. Anti-inflammatory and antibacterial hydrogels have achieved certain research results in the treatment of chronic diabetic wounds, but there are still some technical problems waiting for further improvement. Meanwhile, this paper discusses the prospect of the future development of hydrogels applied in chronic diabetic wounds, aiming to provide systematic theoretical support for the treatment of chronic diabetic wounds in the future.