The relationship between the level of TAT/PIC and utilization rate of mechanical ventilation in critically ill patients

Jiamei LI; Sanyuan Liu; Ruohan LI; Xiaoling Zhang; Yanni Luo; Lei Zhang; Xiaochuang Wang; Gang Wang

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The relationship between the level of TAT/PIC and utilization rate of mechanical ventilation in critically ill patients

VernacularTitle:重症患者TAT/PIC水平与机械通气使用率间的关系
Author: Jiamei LI ¹ ; Sanyuan LIU ² ; Ruohan LI ¹ ; Xiaoling ZHANG ¹ ; Yanni LUO ¹ ; Lei ZHANG ² ; Xiaochuang WANG ¹ ; Gang WANG ¹
Author Information

1. Department of Critical Care Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China
2. Department of Laboratory Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China
Publication Type:Journal Article
Keywords: thrombin-antithrombin Ⅲ complex; plasminase-α2 plasminase inhibitor complex; mechanical ventilation; infection; critical care medicine
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2022;43(6):872-878
CountryChina
Language:Chinese
Abstract: 【Objective】 To investigate the relationship between the level of thrombin-antithrombin complex (TAT)/α2-plasmin inhibitor-plasmin complex (PIC) and the utilization rate of mechanical ventilation (MV) in critically ill patients. 【Methods】 For the cross-sectional study, adult patients who had been admitted to the intensive care unit (ICU) for one day or longer and had a record of the first four tests for thrombosis were enrolled. Age, gender, the results of TAT and PIC, disseminated intravascular coagulation score, treatment, and diagnostic information were retrospectively collected from the hospital information system and laboratory information system. Logistic regression model was used to explore the relationship between TAT/PIC and the MV utilization rate. Interaction analysis and subgroup analysis were conducted to explore whether there was any difference between patients with different age and gender, patients with/without DIC, and with/without infection. 【Results】 A total of 1 176 patients were enrolled in this study. The median of the first TAT/PIC was 15.84 (8.13-33.11) in all the patients. The multivariable Logistic regression model results showed that for every 5 increase in TAT/PIC, the possibility of using MV increased by 2.9% (OR=1.029, 95% CI: 1.008-1.050), and the possibility of using MV in Q3 patients was 1.566 times than that in Q1 patients (OR=1.566, 95% CI: 1.095-2.239); the possibility of using MV in Q4 patients was 2.457 times than that in Q1 patients (OR=2.457, 95% CI: 1.694-3.563). Interaction results showed that the relationship between the level of TAT/PIC and MV usage was different in patients with and without infection (Pinteraction=0.02). Further subgroup analysis showed that in the infected patients (674 cases), the possibility of using MV increased by 5.9% for every 5 increase in TAT/PIC (OR=1.059, 95% CI: 1.022-1.097, P=0.001), while there was no significant difference between different TAT/PIC and MV usage in non-infected patients (502 cases) (OR=1.012, 95% CI: 0.984-1.040, P=0.405). 【Conclusion】 There is a correlation between the level of TAT/PIC and mechanical ventilation in patients with infection in the ICU.