Optimization of ethanol extraction process for Yihuang powder by orthogonal experiment combined with AHP and GA-BP neural network
- VernacularTitle:正交实验结合AHP和GA-BP神经网络优化益黄散醇提工艺
- Author:
Wei WANG
1
;
Wujie YANG
1
;
Yu HAN
2
;
Yueyan AN
1
;
Ji HAO
1
;
Qiang ZHANG
1
;
Chengguo JU
1
Author Information
1. School of Pharmacy，Liaoning University of Traditional Chinese Medicine，Dalian 116600，China
2. Medical Laboratory Science School，Liaoning University of Traditional Chinese Medicine，Shenyang 110847，China
- Publication Type:Journal Article
- Keywords:
Yihuang powder;
ethanol extraction process;
orthogonal experiment;
genetic algorithm;
BP neural network
- From:
China Pharmacy
2024;35(3):327-332
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To optimize ethanol extraction process of Yihuang powder. METHODS An orthogonal experiment was designed by reflux extraction with ethanol volume fraction， liquid-to-material ratio， and extraction time as investigation factors. The parameters used were the contents of hesperidin， nobiletin， tangeretin， gallic acid， chebulagic acid， chebulinic acid， liquiritin， glycyrrhizin， eugenol， and the paste-forming rate. The analytic hierarchy process （AHP） was used to calculate the comprehensive score. The optimal ethanol extraction process parameters of Yihuang powder were determined by verifying the results predicted by orthogonal experiment and genetic algorithm （GA）-back propagation neural network （BP neural network）. RESULTS The optimal ethanol extraction process parameters， as optimized by orthogonal experiment， were as follows: ethanol volume fraction of 60%， liquid-solid ratio of 14∶1 （mL/g)， extraction time of 90 min， and extraction for 2 times. The comprehensive score obtained by verification was 79.19. Meanwhile， the optimal ethanol extraction process parameters， optimized by GA-BP neural network， were ethanol volume fraction of 65%， liquid-solid ratio of 14∶1 （mL/g )， extraction time of 60 min， and extraction for 2 times. The comprehensive score obtained by verification was 85.30， higher than the results obtained from orthogonal experiment. CONCLUSIONS The optimization method of orthogonal experiment combined with GA-BP neural network is superior to the traditional orthogonal experiment optimization method. The optimized ethanol extraction process of Yihuang powder is stable and reliable.
