Mechanism of Traditional Chinese Medicine Intervening in Pyroptosis to Prevent and Treat Bone and Joint Related Diseases： A Review
10.13422/j.cnki.syfjx.20232021
- VernacularTitle:中药干预细胞焦亡防治骨关节相关疾病机制研究进展
- Author:
Jutang CHAI
1
;
Hongxia NING
2
;
Yongzhang LI
1
;
Xiaoyu LIU
3
;
Xiaotao WEI
3
;
Tao LIU
4
;
Zhigang WEN
1
Author Information
1. Hebei Provincial Hospital of Chinese Medicine，Shijiazhuang 050000，China
2. Shijiazhuang Hospital of Traditional Chinese Medicine（TCM），Shijiazhuang 050000，China
3. Gansu University of Chinese Medicine，Lanzhou 730000，China
4. Gansu Provincial Hospital of TCM，Lanzhou 730000，China
- Publication Type:Journal Article
- Keywords:
pyroptosis;
osteoarthritis;
rheumatoid arthritis;
gouty arthritis;
intervertebral disc degeneration;
traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(6):289-298
- CountryChina
- Language:Chinese
-
Abstract:
Osteoarthritis （OA）， rheumatoid arthritis （RA）， gouty arthritis （GA）， and intervertebral disc degeneration （IVDD） are the most common bone and joint-related diseases in clinical practice. They can all affect related joints， leading to joint pain， swelling， dysfunction， and other symptoms. The difference is that OA is mainly caused by joint wear and age-related degradation and is manifested as joint pain， stiffness， and limited movement. RA is an autoimmune disease， manifested as joint pain， swelling， morning stiffness， and systemic symptoms. GA is caused by abnormal uric acid metabolism， manifested as acute arthritis， and IVDD is caused by intervertebral disc degeneration. Studies have shown that the mechanism of the occurrence and development of these bone and joint diseases is extremely complex. Pyroptosis is closely related to these bone and joint-related diseases by participating in bone and joint inflammation， cartilage metabolism imbalance， extracellular matrix degradation， and pathological damage of bone and joint. Inhibition of bone and joint-related pyroptosis will effectively prevent and treat bone and joint-related diseases. At the same time， many studies have confirmed that traditional Chinese medicine （TCM） has a prominent curative effect and obvious advantages in the prevention and treatment of bone and joint-related diseases. TCM can reduce the inflammatory reaction of bone and joints， improve the pathological damage of bone and joint diseases， and relieve bone and joint pain by inhibiting pyroptosis. Therefore， this article aims to briefly explain the relationship between pyroptosis and the occurrence and development of bone and joint-related diseases and summarize the latest research reports on the intervention of pyroptosis in the treatment of bone and joint-related diseases by TCM monomers， TCM extracts， and TCM compounds. It offers new ideas for the in-depth study of the pathogenesis and drug treatment of bone and joint diseases and provides a basis for the clinical use of TCM to prevent and treat bone and joint diseases.
