Role of NLRP3 Inflammasome in IgA Nephropathy and Chinese Medicine Intervention： A Review
10.13422/j.cnki.syfjx.20240994
- VernacularTitle:NLRP3炎症小体在IgA肾病中的作用及中药干预进展
- Author:
Yongfang LIU
1
;
Li ZHOU
2
;
Huiyang LIU
1
;
Rui HUANG
2
;
Zhiying FENG
2
;
Tiantian YIN
2
Author Information
1. Jiujiang Hospital of Traditional Chinese Medicine Affiliated to Jiangxi University of Chinese Medicine，Jiujiang 332000，China
2. Graduate School of Jiangxi University of Chinese Medicine，Nanchang 330004，China
- Publication Type:Journal Article
- Keywords:
IgA nephropathy;
NOD-like receptor protein 3 （NLRP3） inflammasome;
traditional Chinese medicine;
inflammation
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(6):269-279
- CountryChina
- Language:Chinese
-
Abstract:
IgA nephropathy is recognized as the most common primary glomerular disease， with up to 20%-40% of patients developing end-stage kidney disease within 20 years of onset. The deposition of IgA1-containing immune complexes targeting glycosylation defects in the mesangial region and the subsequent inflammation caused by T lymphocyte activation are considered as the main causes of IgA nephropathy， and innate immunity is also involved in the pathogenesis. Nucleotide-binding oligomerization domain （NOD）-like receptor protein 3 （NLRP3） is a newly discovered pattern recognition receptor expressed in renal intrinsic cells such as renal tubular epithelial cells， mesangial cells， and podocytes. Activated by external stimuli， NLRP3 can form NLRP3 inflammasomes with apoptosis-associated speck-like protein containing a caspase recruitment domain （ASC）. The NLRP3 inflammasome can activate cysteine aspartate-specific protease-1 （Caspase-1）， causing the maturation and release of interleukin-18 （IL-18） and interleukin-1β （IL-1β） involved in inflammation. Increasing evidence has suggested that NLRP3 inflammasomes are involved in the pathogenesis and progression of IgA nephropathy and associated with the damage of renal intrinsic cells such as podocytes， mesangial cells， endothelial cells， and renal tubular epithelial cells. Chinese medicine can regulate inflammatory cytokines and their signaling pathways by acting on NLRP3 inflammasomes and related molecules， exerting therapeutic effects on IgA nephropathy. This article introduces the role of NLRP3 inflammasomes in IgA nephropathy and reviews the clinical and experimental research progress of Chinese medicine intervention in IgA nephropathy via NLRP3 inflammasomes， aiming to provide a reference for further research and application of Chinese medicine intervention in the NLRP3 inflammasome as a new therapeutic target.
