Cutaneous metastasis as a diagnostic prelude in a 48-year-old female
- Author:
Nagatoshi M. Ebisawa
1
;
Isabel G. Palabyab‑Imperial
1
;
Leilani R. Senador
1
;
Luella Joy A. Escueta‑Alcos
1
Author Information
- Publication Type:Case Reports
- Keywords: Carcinoma erysipeloides; Cutaneous metastasis
- MeSH: Breast Neoplasms
- From: Journal of the Philippine Dermatological Society 2023;32(2):107-110
- CountryPhilippines
- Language:English
- Abstract: Cutaneous metastasis (CM) describes the spread of a distant primary tumor into the skin. The overall incidence of CM ranges from 5% to 10% with breast cancer having the highest rate in women. CM of breast carcinoma origin may manifest as erysipelas-like erythema on the chest, having distinct raised borders and edema due to lymphatic obstruction termed as carcinoma erysipeloides. In most cases, CM is recognized after the initial diagnosis of primary internal malignancy. However, in 0.6–1% of cases, CM served as the first presenting sign of malignancy. A 48-year-old female presented with multiple, erythematous patches, and plaques with clear-cut raised margins, some topped with violaceous pinpoint papules and nodules on the chest, abdomen, and back. No palpable breast mass was appreciated. There was noted nipple retraction and axillary lymphadenopathy. A 4-mm skin punch biopsy revealed nests of large pleomorphic cells on the papillary dermis admixed with mitotic figures and attempts of ductal formation. CK7 and CEA were positive. Results of ultrasonography and mammogram were highly suspicious of malignancy. Core needle biopsy of the breast mass revealed an invasive ductal carcinoma. In the context of an eczematous presentation on the chest area without palpable nodules or mass on breast examination, a diagnostic challenge is expected. Interestingly, our patient represents a small group of CM having cutaneous lesions as their primary manifestation. A high index of suspicion supplemented with proper clinicopathologic and radiologic correlation is crucial for the diagnosis of CM. A multidisciplinary referral is required for adequate management and overall survival rate.
- Full text:cutaneous_metastasis_as_a_diagnostic_prelude_in_a.7.pdf
