Efficacy of oral lycopene supplementation for photoprotection in Filipino patients in a Tertiary Hospital in Makati: A single-blind randomized controlled trial
- Author:
Katrina Marie A. Torno
1
;
Patricia Anne T. Tinio
1
;
Stephen Thomas F. Lacson
1
Author Information
- Publication Type:Journal Article
- Keywords: Filipino; Fitzpatrick skin phototype III–V; Photoprotection
- MeSH: Lycopene
- From: Journal of the Philippine Dermatological Society 2023;32(2):96-102
- CountryPhilippines
- Language:English
-
Abstract:
Background:Ultraviolet radiation has been proven to result in unwarranted effects on the skin through
reactive oxygen species (ROS) and direct DNA damage. Lycopene, a naturally occurring substance, acts as
an antioxidant by neutralizing ROS.
Objective:The objective of the study was to determine the efficacy of oral lycopene supplementation for photoprotection in adult Filipino patients seen in a tertiary hospital in Makati City.
Design:The study design involves single-blind, parallel, randomized controlled trial.
Methods:Thirty-six Filipino patients aged 18 years old and above with Fitzpatrick Skin Phototype (FSP) III–V were divided into two groups using a computer-generated randomization. Group A received lycopene 500 mg/ soft gel capsule two capsules per orem once daily for 12 weeks, while Group B received no intervention during the entire observation period. Minimal erythema dose (MED) of patients from both groups was assessed by a single treatment-blinded reader at baseline, week 6, and week 12.
Results:Group A showed a significant increase in MED across periods, with a 20.83% increase from baseline at week 6 and a 43.06% increase at week 12. Group B MED remained constant from baseline to week 6 and to week 12. These results show that there is a significant effect in the increase in MED as compared to the control group.
Conclusion:Oral lycopene is effective in increasing the MED of patients and may be used for photoprotection among patients with FSP III–V. - Full text:efficacy_of_oral_lycopene_supplementation_for.5.pdf
