Experimental infection of tick cells with Nipah virus
https://doi.org/10.47665/tb.40.1.009
- Author:
Phoon, W.H.
1
;
Bell-Sakyi, L.
2
;
AbuBakar, S.
3
;
Chang, L.Y.
1
Author Information
1. Department of Medical Microbiology, Universiti Malaya, 50603 Kuala Lumpur, Malaysia
2. Institute of Infection, Veterinary and Ecological Science, University of Liverpool, 146 Brownlow Hill, Liverpool L3 5RF, United Kingdom
3. Tropical Infectious Diseases Research and Education Centre, Universiti Malaya, 50603 Kuala Lumpur, Malaysia
- Publication Type:Journal Article
- Keywords:
Henipavirus infection;
Chiroptera;
ticks;
viral RNA;
electron microscopy.
- From:Tropical Biomedicine
2023;40(No.1):29-36
- CountryMalaysia
- Language:English
-
Abstract:
Nipah virus (NiV), a highly pathogenic henipavirus of the family Paramyxoviridae, which causes fatal
encephalitis in 40-70% of affected patients, was first reported in Malaysia over 20 years ago. Pteropid
bats are the natural hosts of henipaviruses, and ticks have been proposed as a possible link between
bats and mammalian hosts. To investigate this hypothesis, infection of the tick cell line IDE8 with NiV
was examined. Presence of viral RNA and antigen in the NiV-infected tick cells was confirmed. Infectious
virions were recovered from NiV-infected tick cells and ultrastructural features of NiV were observed
by electron microscopy. These results suggest that ticks could support NiV infection, potentially playing
a role in transmission.
- Full text:8.2023my1386.pdf
