Role of apical sodium-dependent bile acid transporter in hepatobiliary diseases
- VernacularTitle:顶端钠依赖性胆汁酸转运蛋白（ASBT）在肝胆疾病中的作用
- Author:
Xiaoxuan XIE
1
;
Lina DU
1
;
Ziyun GUO
1
;
Yan YANG
1
Author Information
- Publication Type:Review
- Keywords: Apical Sodium Dependent Bile Acid Transporter; Bile Acid; Cholestasis
- From: Journal of Clinical Hepatology 2024;40(1):199-203
- CountryChina
- Language:Chinese
- Abstract: Apical sodium-dependent bile acid transporter （ASBT） is a key transporter responsible for intestinal reabsorption of bile acid and plays an important role in maintaining bile acid and cholesterol homeostasis， and its expression is regulated by various factors including transcription factors， nuclear receptors， and intestinal microflora. The abnormal expression and function of ASBT can lead to disorders in the metabolism of bile acid and cholesterol， causing a variety of hepatobiliary diseases. At present， ASBT has attracted wide attention as a therapeutic target. This article elaborates on the biological characteristics and expression regulation mechanism of ASBT and reviews the role of ASBT in hepatobiliary diseases， in order to provide a new direction for the treatment of related diseases.
