Research advances in the immunomodulatory mechanism of galectin-9 and its role in liver diseases

VernacularTitle:半乳糖凝集素-9（Gal-9）介导的免疫调节作用在肝脏疾病中的研究进展
Author: Jun LING ¹ ; Bing ZHU ² ; Weiwei CHEN ² ; Zhuoran WANG ² ; Limei YU ¹ ; Shaoli YOU ²
Author Information

1. Guizhou Provincial Key Laboratory of Cell Engineering， Affiliated Hospital of Zunyi Medical University， Zunyi， Guizhou 563003， China
2. Division of Liver Disease， The Fifth Medical Center of Chinese PLA General Hospital， Beijing 100039， China
Publication Type:Review
Keywords: Galectin-9; Immunomodulation; Liver Diseases
From: Journal of Clinical Hepatology 2024;40(1):193-198
CountryChina
Language:Chinese
Abstract: Galectin-9 （Gal-9） is a member of the galectin family that can specifically recognize and bind to galactosides. Recent studies have shown that Gal-9 is highly expressed in the liver and can help to maintain intrahepatic immune homeostasis and perform biological functions in various liver diseases. This article reviews the immunomodulatory functions of Gal-9 and its role in different liver diseases. Studies have shown that Gal-9 has important biological functions in different liver diseases through multiple pathways. Research on the specific immunomodulatory mechanisms and functions of Gal-9 may help to discover the therapeutic role of Gal-9 in liver diseases.