The mechanism of action of mitochondrial dysfunction in the development of non-alcoholic fatty liver disease
- VernacularTitle:肝线粒体功能障碍在非酒精性脂肪性肝病发病中的作用机制
- Author:
Bingqing YANG
1
;
Jingya YIN
1
;
Qi WANG
1
Author Information
- Publication Type:Review
- Keywords: Non-alcoholic Fatty Liver Disease; Mitochondria， Liver; Oxidative Phosphorylation; Mitochondrial Diseases
- From: Journal of Clinical Hepatology 2024;40(1):147-150
- CountryChina
- Language:Chinese
- Abstract: Nonalcoholic fatty liver disease （NAFLD） has gradually become the main reason affecting human liver health， and many factors are involved in the development and progression of NAFLD. Mitochondria， as the “energy factory” of cells， plays an important role in maintaining normal physiological functions. Studies have shown that hepatic mitochondrial dysfunction promotes the development and progression of NAFLD. This article briefly introduces the latest research advances in the basic characteristics and physiological function of liver mitochondria and reviews new research findings in the association of mitochondrial dysfunction with obesity， simple fatty liver disease， and nonalcoholic steatohepatitis， in order to provide new ideas for the research on targeted mitochondrial therapy for NAFLD.
