Establishment and application of animal models for portal vein thrombosis

VernacularTitle:门静脉血栓动物模型的建立和应用
Author: Zhuang LIU ¹ ; Jihong CHEN ¹ ; Xingshun QI ¹ ; Xiangbo XU ¹ ; Yuzheng ZHUGE ²
Author Information

1. Department of Gastroenterology， General Hospital of Northern Theater Command， Shenyang 110840， China
2. Department of Gastroenterology， Affiliated Drum Tower Hospital of Nanjing University Medical School， Nanjing 210008， China
Publication Type:Journal Article
Keywords: Portal Vein Thrombosis; Disease Models， Animal; Pathogenesis
From: Journal of Clinical Hepatology 2024;40(1):29-32
CountryChina
Language:Chinese
Abstract: Portal vein thrombosis （PVT） refers to thromboembolism that occurs in the extrahepatic main portal vein and/or intrahepatic portal vein branches. PVT is the result of the combined effect of multiple factors， but its pathogenesis remains unclear. Animal models are an important method for exploring the pathophysiological mechanism of PVT. Based on the different species of animals， this article reviews the existing animal models of PVT in terms of modeling methods， principles， advantages and disadvantages， and application.