Evaluation of Fine Needle Biopsy (FNB) for Endoscopic Ultrasound (EUS)-guided tissue acquisition of pancreatic masses to negate the need for rapid on-site evaluation: A randomized control trial
https://doi.org/10.47895/amp.vi0.6817
- Author:
Mark Anthony A. De Lusong
1
;
Nico Nahar I. Pajes
1
Author Information
1. Division of Gastroenterology, Department of Medicine, College of Medicine and Philippine General Hospital, University of the Philippines Manila
- Publication Type:Journal Article
- Keywords:
Pancreatic masses;
Endoscopic ultrasound tissue acquisition;
Diagnostic accuracy
- MeSH:
Pancreatic Neoplasms
- From:
Acta Medica Philippina
2024;58(1):51-56
- CountryPhilippines
- Language:English
-
Abstract:
Background and Objectives:The benefits of rapid on-site evaluation (ROSE) of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) of solid masses have not been convincingly shown in large, randomized trials. New equipment using EUS-guided fine needle biopsy (FNB) allows for more material to be acquired that may obviate the need for ROSE. This study aimed to evaluate if EUS-FNB without ROSE was non-inferior to EUS-FNA with ROSE in solid pancreatic masses (SPMs).
Methods:Patients with SPMs requiring tissue sampling were randomly assigned to undergo either EUS-FNA with ROSE or EUS-FNB without ROSE. The touch-imprint cytology technique was used to perform ROSE. The primary endpoint was diagnostic accuracy and secondary endpoints were specimen quality, complication rates, and procedure time.
Results:Seventy-eight patients were randomized and analyzed (39 EUS-FNA with ROSE and 39 EUS-FNB without
ROSE). Non-significantly different diagnostic accuracies were noted in both groups (97% with ROSE and 100%
without ROSE, P < 0.371). The bloodiness of histologic samples and complication rates were not significantly different between groups. A significantly shorter mean sampling procedural time was noted for EUS-FNB over EUS-FNA with ROSE (30.4 ± 10.4 vs 35.8 ± 9.8 minutes, P < .02).
Conclusions:EUS-FNB demonstrated equal diagnostic accuracy with shorter procedure times in evaluating SPMs compared to EUS-FNA with ROSE. These new-generation FNB needles may obviate the need for ROSE.
- Full text:6817-Article Text-96385-2-10-20240125.pdf
