Research progress on m5C methylation and its prospects in tumor immunotherapy
10.12016/j.issn.2096-1456.2024.02.009
- VernacularTitle:m5C甲基化修饰及其在肿瘤免疫治疗中的研究进展
- Author:
Yunyang LU
1
;
Weidong DU
;
Dongsheng YU
Author Information
1. 中山大学附属口腔医院,光华口腔医学院,广东省口腔重点实验室,广东 广州(510055)
- Keywords:
tumor;
epigenetics;
methylation;
5-methylcytosine;
N6-methyladenosine;
RNA methylation;
immunotherapy;
tumor microenvironment;
m5C regulatory protein
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2024;32(2):143-148
- CountryChina
- Language:Chinese
-
Abstract:
Epigenetic modification plays an important role in the biological regulatory process of eukaryotic cells.Tumor immunotherapy is an important means and clinical strategy for the treatment of some cancers.5-Methylcytosine(m5C)is an important component of the epigenetic regulatory network discovered after m6A and has become a new topic for life science research in recent years.The m5C methylation of RNA can affect the fate of the modified RNA mole-cules and play an important role in various biological processes,including RNA stability,protein synthesis and tran-scriptional regulation.Recent studies have shown that m5C writers,erasers and readers are related to a variety of cellu-lar biological processes and systemic diseases,including the occurrence,metastasis and tumor immune microenviron-ment.m5C methylation can widely affect gene expression and the biological process of tumorigenesis and development at multiple levels,but its specific mechanism and potential interaction with other epigenetic modifications in tumor im-munotherapy are still unclear,and its regulatory mechanism,risk assessment and role in targeted therapy for malignant tumors need to be further studied.This article will review the dynamic regulatory network of m5C,the biological role of m5C modification in solid tumors and potential targets in tumor immunotherapy.
