Signaling Pathways Related to Dilated Cardiomyopathy and Their Regulation by Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20232142
- VernacularTitle:扩张型心肌病相关信号通路及其中医药调控研究进展
- Author:
Yueqing QIU
1
;
Zhentao WANG
1
Author Information
1. Henan University of Traditional Chinese Medicine（TCM），Zhengzhou 450053，China
- Publication Type:Journal Article
- Keywords:
dilated cardiomyopathy;
traditional Chinese medicine;
signaling pathway;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(5):256-264
- CountryChina
- Language:Chinese
-
Abstract:
Dilated cardiomyopathy （DCM） is characterized by the main pathological changes of global cardiac enlargement， especially left ventricular enlargement. Clinical manifestations include decreased heart function， arrhythmia， thromboembolism， and even sudden death. It is one of the refractory cardiovascular diseases. Conservative drug treatment is still the main approach in clinical practice， but due to its unavoidable side effects such as low blood pressure， it is often difficult to achieve a satisfactory prognosis. The combination of traditional Chinese medicine and Western medicine can effectively improve side effects and enhance efficacy. The research has found that nuclear transcription factors-κB （NF-κB）， adenylate activated protein kinase （AMPK）/mammalian rapamycin target protein （mTOR）， transforming growth factor-β （TGF-β）/Smads， Toll like receptors （TLR） 4/c-Jun amino terminal kinase （JNK）， mitogen activated protein kinase （MAPK）， phosphatidylinositol 3-kinase （PI3K）/protein kinase （Akt）， and other signaling pathways play a crucial regulatory role in the occurrence and development of DCM. Traditional Chinese medicine can improve myocardial fibrosis， reverse ventricular remodeling， alleviate oxidative stress， and achieve anti-inflammatory and other effects by regulating the above signaling pathways， thus improving DCM. Due to its multi-target and multi-mechanism characteristics， it has the advantages of high safety and good tolerance and has become an important part of current clinical treatment.
