Regulation of Immune Balance by Traditional Chinese Medicine in Treatment of Cough Variant Asthma： A Review
10.13422/j.cnki.syfjx.20230728
- VernacularTitle:中医药调节免疫平衡治疗咳嗽变异性哮喘研究进展
- Author:
Han YANG
1
;
Yonghuang YAN
2
;
Wenting ZHANG
2
;
Peixuan ZHU
2
;
Fang YAN
3
;
Yujie WU
2
;
Shiqing QIAO
1
;
Tieshan WANG
4
;
Zeqi SU
4
;
Ting WANG
4
Author Information
1. College of Life Science， Beijing University of Chinese Medicine， Beijing 100029， China
2. School of Traditional Chinese Medicine （TCM）， Beijing University of Chinese Medicine， Beijing 100029， China
3. Dongfang Hospital， Beijing University of Chinese Medicine， Beijing 100078， China
4. Beijing Research Institute of Chinese Medicine， Beijing University of Chinese Medicine， Beijing 100029， China
- Publication Type:Review
- Keywords:
traditional Chinese medicine;
cough variant asthma;
immune balance;
T helper cells 1 /T helper cells 2 （Th1/Th2）;
Th17/regulatory T cells （Treg）;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(5):206-212
- CountryChina
- Language:Chinese
-
Abstract:
Cough variant asthma （CVA） is a chronic respiratory disease with cough as its main symptom. The occurrence of CVA is closely related to non-specific airway inflammation， and its pathogenesis involves environmental， genetic， immune， and other factors. In recent years， the advantages of traditional Chinese medicine （TCM） in the treatment of CVA have attracted the attention of experts and scholars in China and abroad， especially its prominent role in regulating immune balance， relieving cough symptoms in CVA patients， and reducing recurrence. T Helper cells 1 （Th1）， T helper cells 2 （Th2）， T helper cells 17 （Th17）， and regulatory T cells （Treg） are derived from CD4+ T cells. Immune imbalance of Th1/Th2 and Th17/Treg is a new hotspot in the pathogenesis of CVA and a potential key target in the treatment of CVA by TCM. Th cell subsets are in dynamic balance under physiological conditions， maintaining respiratory immune homeostasis in which pro-inflammatory cytokines and anti-inflammatory cytokines are balanced. Immature helper T cells （Th0） can be differentiated into Th1， Th2， Th17， Treg， and other cell subsets due to cytokine types in the microenvironment in the stage of CVA maturation. The proliferation of Th2 cells leads to eosinophilic airway inflammation. Excessive differentiation of Th17 cells induces neutrophil airway inflammation. Th1/Th2 and Th17/Treg cells are mutually restricted in number and function， and the immune imbalance of Th1/Th2 and Th17/Treg is easy to aggravate the generation of inflammatory response. Restoring immune balance is particularly important for the airway anti-inflammatory therapy of CVA. In this paper， the imbalance of Th1/Th2 and Th17/Treg and the pathogenesis of CVA were systematically expounded. Meanwhile， the latest research on the regulation of immune imbalance by TCM compound， single TCM， and its effective ingredients in the treatment of CVA was reviewed. It provides ideas and references for revealing the scientific connotation of TCM regulating immune balance therapy of CVA， as well as the development of clinical treatment and basic research of CVA.
