Mechanism of Tumor T Cell Exhaustion from Perspective of ''Sanjiao-Yingwei'' Qi Transformation Malfunction
10.13422/j.cnki.syfjx.20230729
- VernacularTitle:从“三焦-营卫”气化失常角度探析肿瘤T细胞耗竭机制
- Author:
Xinhao TANG
1
;
Bowen CHU
2
;
Yuanyuan QIN
3
;
Yeling LIU
1
;
Xinyan SHU
1
;
Mianhua WU
3
;
Gang YIN
4
;
Jianguo DAI
1
Author Information
1. School of Medicine & Holistic Integrative Medicine， Nanjing University of Chinese Medicine， Nanjing 210023， China
2. Beijing Union Medical College， Chinese Academy of Medical Sciences， Beijing 100730， China
3. The First School of Clinical Medicine， Nanjing University of Chinese Medicine， Nanjing 210023， China
4. School of Chinese Medicine & Integrated Chinese and Western Medicine， Nanjing University of Chinese Medicine， Nanjing 210023， China
- Publication Type:Journal Article
- Keywords:
T cell exhaustion;
Sanjiao-Yingwei;
tumor;
immunometabolism;
network pharmacology;
bioinformatics
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(5):176-185
- CountryChina
- Language:Chinese
-
Abstract:
In order to promote the innovative application of Sanjiao theory and Yingwei theory， this paper tries to apply the ''Sanjiao-Yingwei'' Qi transformation theory to the treatment of tumor diseases， integrating it with T cell exhaustion mechanism to elaborate on its scientific connotation and using network pharmacology and bioinformatics to elucidate the correlation between the anti-tumor mechanism of ''Sanjiao-Yingwei'' Qi transformation and T cell exhaustion. The ''Sanjiao-Yingwei'' Qi transformation function is closely related to the immunometabolic ability of the human body， and the ''Sanjiao-Yingwei'' Qi transformation system constitutes the immunometabolic exchange system within and outside the cellular environment. Cancer toxicity is generated by the fuzzy Sanjiao Qi， and the long-term fuzzy Sanjiao Qi is the primary factor leading to T cell exhaustion， which is related to the long-term activation of T cell receptors by the high tumor antigen load in the tumor microenvironment. Qi transformation malfunction of the Sanjiao produces phlegm and collects stasis， which contributes to T cell exhaustion and is correlated with nutrient deprivation， lipid accumulation， and high lactate levels in the immunosuppressed tumor microenvironment， as well as with the release of transforming growth factor-β and upregulated expression of programmed death receptor-1 by tumor-associated fibroblasts and platelets in the tumor microenvironment. Ying and Wei damage due to Sanjiao Qi transformation malfunction is similar to the abnormal manifestations such as progressive loss of exhausted T cell effector function and disturbance of cellular energy metabolism. Guizhi decoction， Shengming decoction， and Wendan decoction can correct T cell exhaustion and exert anti-tumor effects through multi-target and multi-pathways by regulating ''Sanjiao-Yingwei'' Qi transformation， and hypoxia inducible factor-1α （HIF-1α） may be one of the main pathways to correct T cell exhaustion. It was found that HIF-1α may be one of the important prognostic indicators in common tumors by bioinformatics. The use of the ''Sanjiao-Yingwei'' Qi transformation method may play an important part in improving the prognosis of tumor patients in clinical practice.
