Mechanism of Bushen Yijing Method in Treatment of Oligoasthenozoospermia Based on Intestinal Microbiota
10.13422/j.cnki.syfjx.20230795
- VernacularTitle:基于肠道菌群探讨补肾益精法治疗少弱精子症的作用机制
- Author:
Nianwen HUANG
1
;
Haisong LI
1
;
Huanzhou BI
2
;
Bin WANG
1
;
Juanlong FENG
1
;
Longji SUN
1
;
Jisheng WANG
1
;
Chengli WANG
3
Author Information
1. Dongzhimen Hospital，Beijing University of Chinese Medicine，Beijing 100700，China
2. Shenzhen Hospital，Beijing University of Chinese Medicine，Shenzhen 518172，China
3. Dongfang Hospital，Beijing University of Chinese Medicine，Beijing 100078，China
- Publication Type:Journal Article
- Keywords:
oligoasthenozoospermia;
intestinal microbiota;
deficiency of kidney essence;
tonifying the kidney and strengthening the essence;
traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(5):170-175
- CountryChina
- Language:Chinese
-
Abstract:
Oligoasthenozoospermia is the main cause of male infertility， with complex and diverse causes. Currently， there are still some unclear causes of oligoasthenozoospermia in clinical practice， known as idiopathic oligoasthenozoospermia. With the development of high-throughput sequencing technology， it has been found that intestinal microbiota disorder may be an important promoting factor for the onset of oligoasthenozoospermia. Traditional Chinese medicine believes that "deficiency of kidney essence" is the core pathogenesis of oligoasthenozoospermia. In clinical practice， the method of tonifying the kidney and strengthening the essence has a significant therapeutic effect on oligoasthenozoospermia， but its mechanism of action has not been fully elucidated. Based on the basic theories of traditional Chinese medicine and molecular biology research， it has been found that there is a similarity between "kidney essence" and intestinal microbiota. During the onset of oligoasthenozoospermia， the disorder of intestinal microbiota has similarities with the pathogenesis of "deficiency of kidney essence" in traditional Chinese medicine. Moreover， traditional Chinese medicine for tonifying the kidney and strengthening the essence can regulate the disorder of intestinal microbiota， which may be one of the effective mechanisms for the treatment of oligoasthenozoospermia with the Bushen Yijing method. Based on this， this article explored the mechanism of Bushen Yijing method of traditional Chinese medicine in treating oligoasthenozoospermia from the perspective of intestinal microbiota， so as to provide new ideas for the treatment of oligoasthenozoospermia with traditional Chinese medicine.
