Association between Serotonin Transporter Linked Promoter Region(5-HTTLPR) Polymorphism and Age of Onset of Obsessive-Compulsive Disorder.
- Author:
Se Joo KIM
1
;
Chan Hyung KIM
;
Hong Shick LEE
Author Information
1. Department of Psychiatry, Hallym University College of Medicine, Anyang, Korea.
- Publication Type:Original Article
- Keywords:
Serotonin transporter polymorphism;
Early-onset;
Late-onset;
Obsessive-compulsive disorder
- MeSH:
Age of Onset*;
Alleles;
DNA;
Electrophoresis;
Gene Frequency;
Genotype;
Humans;
Obsessive-Compulsive Disorder*;
Polymerase Chain Reaction;
Serotonin Plasma Membrane Transport Proteins*;
Serotonin*
- From:Korean Journal of Psychopharmacology
2005;16(1):76-80
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Many researches strongly suggest that early- and late-onset obsessive-compulsive disorder (OCD) represent separate subtypes of the disorder, possibly with distinct underlying pathogeneses. The aim of this study was to determine the association between 5-HTTLPR genotypes and the onset of OCD. METHODS: We recruited 124 OCD patients and classified them into an early-onset group (age of onset <18 years) and a late onset-group (age of onset >or= 18 years). From the blood, DNA was isolated using standard techniques and the 5-HTTLPR polymorphism was genotyped by polymerase chain reaction and electrophoresis. We classified the subject as s/s, s/l, and l/l group according to their genotype. We also combined the s/l and l/l genotypes (l allele non-carrier) and compared these with the s/s genotype (l allele non-carrier) for our analysis. Genotype and allele frequencies of early- and late-onset OCD were analyzed by chi-square statistics. RESULTS: The frequencies of s/l+l/l genotype and l allele in early-onset OCD group were significantly higher than late-onset OCD group. CONCLUSION: These results suggest that a 5-HTTLPR polymorphism is an important factor in the onset of OCD.
