Effects of Guhong Injection on Expression of Vascular Endothelial Growth Factor in Cortex after Cerebral Ischemia-reperfusion in Rats
- VernacularTitle:谷红注射液对脑缺血再灌注大鼠皮层血管内皮生长因子表达的影响
- Author:
Rui ZHANG
;
Zhen LIANG
;
Nan YANG
;
Chao JI
;
Yan-yong LIU
;
Ping-ping ZUO
- Publication Type:Journal Article
- Keywords:
cerebral ischemia-reperfusion, Guhong injection, vascular endothelial growth factor, rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2015;21(7):770-772
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of Guhong injection on the expression of vascular endothelial growth factor (VEGF) in the cortex 14 days after cerebral ischemia-reperfusion. Methods 30 male Sprague-Dawley rats were divided into sham group (n=6), ischemia group (n=6), aceglutamide injection group (n=6), Honghua injection group (n=6) and Guhong injection group (n=6). The middle cerebral arteries of all the rats were occluded for 2 hours and reperfusion, except the sham group. Drugs were administered once a day 24 hours after reperfusion. The expression of VEGF in cortex was detected with enzyme-linked immunosorbent assay (ELISA) 14 days after reperfusion. Results The expression of VEGF decreased in the ischemia group compared with the sham group (P<0.001), and it increased both in the aceglutamide and Guhong injection groups compared with the ischemia group (P<0.05). Conclusion Guhong injection can significantly increase the expression of VEGF in the cortex 14 days after ischemia-reperfusion, which may be one of the ways for neuro-protection.
