Advances in research on application of bacteria combined with nanotechnology for tumor diagnosis and treatment
10.13200/j.cnki.cjb.004148
- VernacularTitle:基于结合纳米技术的细菌用于肿瘤诊疗的研究进展
- Author:
XUE Xin
- Publication Type:Journal Article
- Keywords:
Bacteria;
Nanotechnology;
Tumor diagnosis and treatment
- From:
Chinese Journal of Biologicals
2024;37(1):117-124+128
- CountryChina
- Language:Chinese
-
Abstract:
Cancer diagnosis and treatment has always been a hot spot in clinical and basic scientific research. In recent years,scientists have developed a large number of tumor diagnosis and treatment methods based on bacteria combined with nanotechnology. Compared with pure bacterial diagnosis and treatment,bacterial diagnosis and treatment combined with nanotechnology can produce multiple synergistic effects,thereby improving the efficacy of tumor diagnosis and treatment.The characteristics of bacteria such as environmental sensitivity,tropism,motility and hypoxia growth combined organically with nanotechnology can increase the solubility of insoluble drugs,promote drug lysosomal escape,and avoid phagocytosis and clearance of the reticuloendothelial system to construct a new type of bacterial micro/nano diagnosis and treatment platform,thereby achieving the precise tumor diagnosis and controlled drug release. This paper reviewed the research progress of bacteria combined with nanotechnology for tumor diagnosis and treatment in recent years and the challenges and possible solutions,so as to provide reference for promoting the rapid development of tumor diagnosis and treatment research.
