Progress in research on B class CpG oligodeoxynucleotides in bacterial vaccines
10.13200/j.cnki.cjb.003960
- VernacularTitle:B型CpG寡聚脱氧核苷酸在细菌性疫苗中的研究进展
- Author:
SUN Min
- Publication Type:Journal Article
- Keywords:
B class CpG oligonucleotide;
Adjuvants;
Disease prevention and treatment;
Bacterial vaccines
- From:
Chinese Journal of Biologicals
2024;37(1):106-112
- CountryChina
- Language:Chinese
-
Abstract:
CpG oligonucleotide(CpG ODN)is a synthetic oligodeoxynucleotide containing non-methylated CpG,which has broad application prospects in disease prevention and clinical treatment. Among them,B class CpG ODN is widely used in vaccine research because of its strong immune stimulation and some motifs have entered the clinical research stage. At the same time,the problem of bacterial resistance in clinical treatment has become increasingly serious,and the development of bacterial vaccine with B class CpG ODN as adjuvant has become a research hotspot. This paper reviewed the current research status and related progress of the existing B class CpG ODN 1826,2006,2007 and 1668 motifs in bacterial vaccines,with a view to providing a reference for the subsequent development and application of bacterial vaccines.
