Research progress on herpes simplex virus membrane fusion protein interactions

VernacularTitle:单纯疱疹病毒膜融合蛋白相互作用的研究进展
Author: HU Jingping
Publication Type:Journal Article
Keywords: Herpes simplex virus(HSV); Glycoprotein structure; Infection mechanism
From: Chinese Journal of Biologicals 2024;37(1):92-98
CountryChina
Language:Chinese
Abstract: Herpes simplex virus(HSV)is a ubiquitous enveloped virus containing double-stranded DNA. HSV-1 infection can cause inflammation of the lips,conjunctivitis and encephalitis,HSV-2 infection can cause genital herpes at many ages,and both viruses can establish lifelong latent infection in the body. Membrane fusion triggered by the interaction of various HSV membrane proteins is an important way for viruses to enter host cells. This review introduced the conserved core fusion mechanism of HSV composed of four viral glycoproteins gD,gH,gL and gB by analyzing the structure of glycoproteins and their interaction modes. Since there is currently no HSV vaccine approved for marketing in the world,it is of great significance to study the mode of action of HSV and host cells for the development of vaccines