Mitigating the dilemma in dementia: A case series of the first amyloid brain PET scans in the Philippines
- Author:
Lara Triccia C. Luistro
1
;
Eduardo Erasto S. Ongkeko
1
,
2
Author Information
1. Department of Nuclear Medicine and Theranostics, St. Lukes Medical Center, Global City
2. Department of Nuclear Medicine and Theranostics, St. Lukes Medical Center, Quezon City
- Publication Type:Journal Article
- Keywords:
Amyloid PET;
F-18 Florbetaben
- MeSH:
Alzheimer Disease;
Diagnostic Imaging
- From:
The Philippine Journal of Nuclear Medicine
2023;18(2):20-31
- CountryPhilippines
- Language:English
-
Abstract:
Diagnosis of Alzheimer dementia is done clinically using criteria set by different neurological associations.
Inevitably, clinicians encounter cases that do not fulfill the set definitions and have to resort to supporting data
to form a clinical judgment. Part of the ancillary work-up for dementia is the brain amyloid PET scan that has
recently been available in the Philippines. It involves a radiopharmaceutical with high-affinity binding to
amyloid plaques which for a time were thought to be central pathological finding for Alzheimer dementia. This
study describes the first four amyloid PET scans in the Philippines and detail the protocol as well as
interpretation of such studies. The procedure is not as simple and reproducible as one might think hence
following the recommended protocol and interpretation guidelines are of utmost importance. We recommend
standardization of the reporting of results for all centers that will cater to patients being worked up for
dementia, which include reporting SUVRs for both whole cerebellum and cerebellar cortex. More studies are
recommended to generate a local Florbetaben SUVR cutoff.
- Full text:18 (2) article 3.pdf
