Effects of diabetes and obesity on renal function recovery in patients under going laparoscopic partial nephrectomy
10.3969/j.issn.1009-8291.2023.03.007
- VernacularTitle:糖尿病及肥胖对腹腔镜肾部分切除患者肾功能恢复的影响
- Author:
Runjin WANG
1
;
Jiaxing MA
2
;
Wahafu WASILIJIANG
3
;
Yun CUI
1
;
Mingshuai WANG
3
;
Min ZHANG
4
;
Yinong NIU
5
Author Information
1. Department of Urology, Capital Medical University Affiliated Beijing Chao-yang Hospital, Beijing 100020
2. Department of Emergency, Capital Medical University Affiliated Beijing Chao-yang Hospital, Beijing 100020
3. Department of Urology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Cancer Center/National Clinical Research Center for Cancer, Beijing 100021
4. Department of Nephrology, Capital Medical University Affiliated Beijing Chaoyang Hospital, Beijing 100020
5. Department of Urology, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing 100038, China
- Publication Type:Journal Article
- Keywords:
renal tumor;
diabetes;
obesity;
acute kidney injury
- From:
Journal of Modern Urology
2023;28(3):206-211
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the effects of diabetes and/or obesity on the incidence of acute kidney injury (AKI) and long-term renal function recovery in patients undergoing laparoscopic partial nephrectomy. 【Methods】 A retrospective analysis was performed on 221 patients who underwent laparoscopic partial nephrectomy in Beijing Chaoyang Hospital during Jan.2018 and Dec.2019. Baseline data, incidence of AKI, and renal function recovery after 12 months were analyzed in the diabetic, non-diabetic, diabetic + obese and diabetic + non-obese groups, with estimated glomerular filtration rate (eGFR) reaching 90% of the preoperative level as the standard. Risk factors of AKI were analyzed with univariate and multivariate regression analyses. 【Results】 Compared with the non-diabetic group, the diabetic group had lower preoperative eGFR [ (79.1±12.1)mL/ (min·1.73 m2 )vs. (85.3±10.7)mL/ (min·1.73 m2 ), P=0.01] , higher incidence of AKI (14.0% vs. 11.8%), and lower proportion of patients whose renal function recovered to at least 90% of the preoperative level (73.1% vs.83.5%). Patients with diabetes and obesity were more likely to develop AKI (31.3% vs.3.7%, P=0.039), and diabetic patients without obesity had better renal function recovery (81.3% vs. 60.0%). Multivariate analysis showed gender and operation time were the independent risk factors of AKI. 【Conclusion】 There were no significant differences between diabetic and non-diabetic patients in the incidence of postoperative AKI, or rate of renal function recovery 12 months after surgery. The incidence of AKI significantly increased in diabetic patients with obesity, and the renal function recovery rate decreased one year after surgery. Gender and operation time were the independent risk factors of AKI.
