Clinicopathological features and prognosis of clear cell papillary renal cell carcinoma
10.3969/j.issn.1009-8291.2023.03.003
- VernacularTitle:透明细胞乳头状肾细胞癌临床病理特征与预后分析
- Author:
Yufeng GU
1
;
Jianping DA
1
;
Yulin ZHOU
1
;
Silun GE
1
;
He MIAO
1
;
Xiaodong ZHAO
1
;
Le QU
1
;
Wenquan ZHOU
1
;
Song XU
1
Author Information
1. Department of Urology, Affiliated Jinling Hospital, Medical College of Nanjing University, Nanjing 210002, China
- Publication Type:Journal Article
- Keywords:
renal cell carcinoma;
clear cell papillary renal cell carcinoma;
clinicopathology;
clear cell renal cell carcinoma;
papillary renal cell carcinoma;
prognosis
- From:
Journal of Modern Urology
2023;28(3):186-191
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the clinicopathological features and prognosis of clear cell papillary renal cell carcinoma (CCPRCC). 【Methods】 The clinicopathological and follow-up data of 40 CCPRCC patients treated during Jun. 2011 and Oct.2021 were retrospectively analyzed. The prognosis was compared with that of 40 cases of clear cell renal cell carcinoma (ccRCC) and 19 cases of papillary renal cell carcinoma (PRCC) treated in the same period. Survival analysis was performed by Log-rank test and Kaplan-Meier survival curves were plotted. 【Results】 Among the 40 patients, 28 were male and 12 were female, aged 31-84 years; 38 cases had unilateral and 2 cases had bilateral tumors; 3 cases had multifocal lesions. All patients received surgery. The maximum diameter of the masses ranged from 3.0 to 95.0 mm, with an average of (27.6±18.1) mm. Pathological grade was Fuhrman 1-2 in all cases. Immunohistochemical tests were positive for CK7 and CA-IX. During the follow-up of 5-129 (average 56) months, 1 case died after bone metastasis, 2 had ipsilateral recurrence, and 1 developed primary esophageal cancer. CCPRCC patients had a significantly better prognosis than CCRCC (P<0.001) and PRCC (P=0.005) patients, while there was no significant difference in the prognosis between CCRCC and PRCC patients (P=0.93). 【Conclusions】 CCPRCC has low malignancy. The diagnosis relies on characteristic pathological and immunohistochemical features. Surgery is an effective treatment. CCPRCC has a better overall prognosis than CCRCC and PRCC.
