Clinical characteristics and risk factors of renal function deterioration in children with renal dysplasia complicated with chronic kidney disease
10.3969/j.issn.1009-8291.2023.04.006
- VernacularTitle:儿童肾发育不良合并慢性肾脏病的临床特征及肾功能恶化的危险因素分析
- Author:
Xuan WANG
1
;
Qingtao ZHONG
1
;
Li ZHANG
1
;
Xin HE
1
;
Deying ZHANG
1
;
Yunfeng HE
2
;
Xing LIU
1
;
Dawei HE
1
;
Tao LIN
1
;
Xuliang LI
1
;
Guanghui WEI
1
Author Information
1. Department of Urology, Children’s Hospital of Chongqing Medical University, Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Key Laboratory of Child Development and Disorders of Ministry of Education, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014
2. Department of Urology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
- Publication Type:Journal Article
- Keywords:
renal dysplasia;
chronic kidney disease;
children;
concomitant disease;
Cox regression analysis
- From:
Journal of Modern Urology
2023;28(4):297-301
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To explore the clinical characteristics and risk factors of renal function deterioration in children with renal dysplasia and chronic kidney disease (CKD), so as to provide a basis for the diagnosis, treatment, and management. 【Methods】 The clinical data of children with renal dysplasia complicated with CKD treated in the Children’s Hospital of Chongqing Medical University during 2012 and 2022 were retrospectively analyzed, including the gender, age of diagnosis, growth index, concomitant malformation and complications. According to the diagnostic criteria and staging standard of KDIGO2020 guidelines, patients with disease deteriorated to CKD stage 4-5 were enrolled into the regression group. Factors affecting the deterioration of renal function were determined with Cox regression analysis. 【Results】 A total of 122 children were involved, including 66 (54.1%) with CKD stag 4-5. There were more boys than girls. Bilateral and unilateral renal dysplasia occurred in 88 (72.13%) and 34 (27.87%) cases, respectively, and 64 (52.46%) cases were complicated with other urinary diseases. There were significant differences in weight, height and body mass index (BMI) among patients with CKD stage 1-5 (P<0.01). The age of onset of CKD <10 years, BMI lower than the 3rd percentile of the same sex and age, bilateral renal dysplasia, and one or more complications of congenital renal and urinary tract abnormalities (CAKUT) were the risk factors of deterioration of renal function (P<0.05). 【Conclusion】 Renal dysplasia complicated with CKD are more common in boys, with high incidence of bilateral renal dysplasia. Bilateral renal dysplasia, age of onset of CKD <10 years, BMI lower than 3% and complications are important influencing factors of renal dysplasia in children with CKD.
