A retrospective study and value analysis of erythropoietin in improving postoperative anemia in renal transplant patients
10.3969/j.issn.1009-8291.2023.05.012
- VernacularTitle:肾移植后贫血患者早期应用促红细胞生成素的临床效果分析
- Author:
Yilun CHEN
1
;
Yu HUI
1
;
Kefeng WU
1
;
Yunjie GUO
1
;
Xuedong WEI
1
;
Yuhua HUANG
1
;
Jianquan HOU
1
,
2
Author Information
1. Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou 215006
2. Department of Urology, Dushu Lake Hospital Affiliated to Suzhou University, Suzhou 215100, China
- Publication Type:Journal Article
- Keywords:
kidney transplantation;
erythropoietin;
anemia after transplantation;
delayed graft function;
serum creatinine
- From:
Journal of Modern Urology
2023;28(5):424-428
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To explore the effects of early application of erythropoietin (EPO) in patients with anemia after renal transplantation. 【Methods】 Patients who underwent renal transplantation in the First Affiliated Hospital of Soochow University were retrospectively analyzed. According to whether EPO was applied after operation, the patients were divided into EPO group and routine group. Patients with delayed renal function recovery were excluded, and the remaining patients were further analyzed. The general, laboratory and follow-up data of the two groups were compared, and adverse drug reactions were observed. 【Results】 The hemoglobin (P=0.026), red blood cell count (P=0.038) and hematocrit (P=0.011) in EPO group were higher than those in the routine group 2 weeks after operation, while the postoperative serum creatinine level was lower (P=0.001). Since the first week after operation, the reticulocyte count in EPO group was significantly higher than that in routine group (P<0.01). There was a negative correlation between hemoglobin and serum creatinine in EPO group at week 1 (r=-0.375, P=0.010) and week 2 (r=-0.386, P=0.008). During the treatment, 6 patients showed transient elevation of serum potassium, which returned to normal after symptomatic treatment, and no obvious adverse drug reactions were observed. 【Conclusion】 Continuous application of erythropoietin in the early stage after renal transplantation can significantly improve anemia in renal transplant patients and promote the recovery of renal function.
