Expressions of P53 and Ki-67 in prostate cancer and the clinicopathological significance
10.3969/j.issn.1009-8291.2023.05.011
- VernacularTitle:P53、Ki-67蛋白在前列腺癌的表达及其临床意义
- Author:
Pengjie WU
1
;
Wei ZHANG
2
;
Shengjie LIU
1
;
Gang ZHU
1
;
Hong MA
1
;
Lingfeng MENG
1
;
Zheng ZHANG
3
;
Yaoguang ZHANG
1
;
Dong WEI
1
;
Ze YANG
3
;
Ben WAN
1
;
Jianye WANG
1
Author Information
1. Department of Urology, National Health Commission, Beijing Hospital (National Center of Gerontolgy/Institute of Geriatric Medicine, Chinese Academy of Medical Sciences), Beijing 100730, China
2. Department of Pathology, National Health Commission, Beijing Hospital (National Center of Gerontolgy/Institute of Geriatric Medicine, Chinese Academy of Medical Sciences), Beijing 100730, China
3. Beijing Institute of Geriatrics, National Health Commission, Beijing Hospital (National Center of Gerontolgy/Institute of Geriatric Medicine, Chinese Academy of Medical Sciences), Beijing 100730, China
- Publication Type:Journal Article
- Keywords:
prostate cancer;
P53 protein;
tumor stage;
Ki-67;
immunohistochemistry
- From:
Journal of Modern Urology
2023;28(5):421-423
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the expressions of P53 and Ki-67 in prostate cancer (PCa)and to explore their correlation with the clinicopathological characteristics. 【Methods】 The expressions of P53 and Ki-67 in 90 PCa patients were detected with immunohistochemistry. Patients’ age, preoperative prostate-specific antigen (PSA) level, postoperative Gleason score, pathological stage, and invasion of neurovascular cancer embolus of all patients were recorded. The relationship of P53 expression with the above indexes was evaluated. 【Results】 The positive rates of P53 and Ki-67 were 27.8% (25/90) and 46.7% (42/90), respectively. The positive rate of P53 in pT2 and pT3-T4 stage groups were 19.7% (13/66) and 50.0% (12/24) (P=0.005), and the positive rate of Ki-67 were 36.4% (24/66) and 75.0% (18/24) (P=0.001), respectively. The positive rate of Ki-67 in Gleason score ≤6, ≤7 and ≥8 groups were 30.4%, 53.8% and 66.7%, respectively, with statistical difference. Positive expression of P53 was related to Ki-67 expression, but not to patients’ age, preoperative PSA level, postoperative Gleason score and nerve and invasion of neurovascular cancer embolus. 【Conclusion】 P53 expression is related to tumor stage and Ki-67, while Ki-67 expression is associated with tumor stage ang grade.
