Comparison of efficacy and safety of PN and RN in the treatment of stage T1b and T2a renal cell carcinoma
10.3969/j.issn.1009-8291.2023.05.005
- VernacularTitle:PN与RN治疗T1b和T2a期肾细胞癌疗效及安全性比较的分析
- Author:
Jiyi DENG
1
;
Sicheng WU
1
;
Liangwen LIN
1
;
Weimin CHEN
1
;
Zhengbang HU
2
Author Information
1. Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang 330000, China
2. Department of Emergency, The First Affiliated Hospital of Nanchang University, Nanchang 330000, China
- Publication Type:Journal Article
- Keywords:
renal cell carcinoma;
partial nephrectomy;
radical nephrectomy;
overall survival
- From:
Journal of Modern Urology
2023;28(5):387-393
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To compare the efficacy, safety and survival of partial nephrectomy (PN) and radical nephrectomy (RN) in the treatment of clinical T1b and T2a renal cell carcinoma (RCC). 【Methods】 A total of 115 patients with stage T1b and T2a RCC treated during Apr.2014 and Jul.2017 were retrospectively analyzed. According to the different surgical methods, the patients were divided into PN group (n=55) and RN group (n=60). The clinical data and prognosis of the two groups were compared. 【Results】 There were no significant differences in the general clinical data and perioperative related factors between the two groups (P>0.05). The incidence of complications was significantly higher in PN group than in RN group (P=0.024), but there was no significant difference in serious complications (Clavien grade ≥3) (P>0.05). In terms of renal function recovery, there was no significant difference in serum creatinine between the two groups before operation (P>0.05), but the serum creatinine was significantly lower in PN group than in RN group on the 1st day, 3rd, 6th and 12th months after operation (P<0.05). After more than 5 years of follow-up, there was no significant difference in 5-year survival rate, overall survival rate, recurrence and metastasis rate, and cancer specific survival rate between the two groups (P>0.05). 【Conclusion】 Both PN and RN are safe and effective in the treatment of stage T1b and T2a RCC, and can achieve good oncological control effects. Compared with RN, PN can fully and effectively protect the postoperative renal function, but it causes more surgical complications. However, there is no significant difference in severe complications (Clavien grade ≥3).
