Influencing factors of survival and prognosis of patients with bladder urothelial carcinoma after surgical treatment and recommendation of an artificial intelligence algorithm
10.3969/j.issn.1009-8291.2023.06.005
- VernacularTitle:膀胱癌患者手术治疗生存预后影响因素分析与人工智能推荐算法初探
- Author:
Yue ZHANG
1
;
Ce ZHANG
2
;
Bo YANG
1
;
Huiwen SHEN
3
;
Deyuan MA
3
;
Lijie WEN
1
;
Wanlong TAN
4
;
Yang YU
1
Author Information
1. Department of Urology, The Second Hospital of Dalian Medical University, Dalian 116000
2. Department of Development Planning and Quality Management, The Second Hospital of Dalian Medical University, Dalian 116000
3. Department of Pharmacy, The Second Hospital of Dalian Medical University, Dalian 116000
4. Department of Urology, Nanfang Hospital of Southern Medical University, Guangzhou 510080, China
- Publication Type:Journal Article
- Keywords:
bladder urothelial carcinoma;
surgical treatment;
deep learning algorithm;
survival prognosis;
surgery prognosis system
- From:
Journal of Modern Urology
2023;28(6):480-486
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To explore the factors influencing the survival and prognosis of patients with bladder urothelial carcinoma (BUC) after surgical treatment, and to establish an artificial intelligence algorithm to predict the effects of different surgical regimens. 【Methods】 BUC patients treated with surgery during Jan.2007 and Jan.2019 in The Second Hospital of Dalian Medical University and Nanfang Hospital of Southern Medical University were enrolled. The complete clinical and follow-up data were collected. Deep neural network (DNN) was used to establish an artificial intelligence algorithm model. A prediction model of survival and prognosis was established, and the influencing factors of survival were explored and ranked by the artificial intelligence algorithm. 【Results】 A total of 832 patients were involved, including 438 (52.64%) treated in The Second Hospital of Dalian Medical University, and 394 (47.36%) treated in Nanfang Hospital of Southern Medical University. Of all cases, 579 (69.6%) were non-muscle invasive bladder cancer, and 253 (30.4%) were muscle invasive bladder cancer. Transurethral resection of bladder tumor was conducted in 539 (64.8%) cases, partial cystectomy in 66 (7.9%) cases, and total cystectomy in 227 (27.3%) cases. The data of patients treated in Second Hospital of Dalian Medical University were used for DNN modeling, and the data of patients treated in Nanfang Hospital of Southern Medical University were used for external verification after modeling. Finally, it was concluded that the factors affecting survival and prognosis were T stage, pathological grade, hypertension or cardiovascular and cerebrovascular disease, hemoglobin, blood calcium, smoking, albumin, lymphocytes, age, ratio of albumin/globulin, operation method, N stage, and creatinine clearance rate in descending order. The model could be used for preoperative prediction. 【Conclusion】 Through DNN modeling and external verification, the influencing factors of postoperative survival can be predicted for patients with bladder cancer, and the surgical effects can also be predicted before operation. The model can provide artificial intelligence algorithm support for the selection of surgical methods and postoperative follow-up plans.
