Clinical and pathological characteristics of small cell carcinoma of bladder and the efficacy of neoadjuvant therapy

Shahatiaili AKEZHOULI; Lei QIAN; Tianxiang ZHANG; Di JIN; Ruiyun ZHANG; Haige CHEN

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Clinical and pathological characteristics of small cell carcinoma of bladder and the efficacy of neoadjuvant therapy

VernacularTitle:膀胱小细胞癌临床病理特征及新辅助治疗疗效
Author: Shahatiaili AKEZHOULI ¹ ; Lei QIAN ¹ ; Tianxiang ZHANG ¹ ; Di JIN ¹ ; Ruiyun ZHANG ¹ ; Haige CHEN ¹
Author Information

1. Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China
Publication Type:Journal Article
Keywords: small cell carcinoma of bladder; clinical and pathological features; prognostic factors; neoadjuvant therapy; immunotherapy
From: Journal of Modern Urology 2023;28(6):474-479
CountryChina
Language:Chinese
Abstract: 【Objective】 To investigate the clinical characteristics and prognostic factors of small cell carcinoma of bladder (SCCB), and to explore the efficacy of neoadjuvant therapy. 【Methods】 Clinical information of 47 SCCB patients were retrospectively collected, and the clinical and pathological features were compared with those of urothelial carcinoma (UBC). The prognostic factors and efficacy of neoadjuvant therapy were also investigated. 【Results】 SCCB had higher baseline tumor staging, and was more likely to invade the muscle (100%) and metastasize distantly (21.3%). The overall survival was poor (median: 13.1 months, 1-year survival rate: 53.7%, 5-year overall survival rate: 15.4%). Tumor T staging was a risk factor for SCCB, while neoadjuvant therapy was an independent protective factor that significantly reduced the risk of recurrence and metastasis (HR: 0.189, 95%CI: 0.051-0.697, P=0.012) and death (HR: 0.177, 95%CI: 0.045-0.698, P=0.013), and significantly improved disease-free survival and overall survival. In addition, compared with neoadjuvant chemotherapy alone, neoadjuvant chemotherapy combined with immunotherapy could improve the pathological complete response rate. 【Conclusion】 SCCB is highly malignant and prone to metastasis, and has a poor prognosis. Neoadjuvant therapy combined with radical cystectomy is recommended as the first-line treatment.