Value of normalized apparent diffusion coefficient in predicting HER2 expression in bladder cancer
10.3969/j.issn.1009-8291.2023.06.002
- VernacularTitle:标化ADC值在预测膀胱癌患者人表皮生长因子受体2表达状态中的应用价值
- Author:
Ruixi YU
1
;
Lingkai CAI
1
;
Kai LI
1
;
Juntao ZHUANG
1
;
Qikai WU
1
;
Peikun LIU
1
;
Qiang CAO
1
;
Pengchao LI
1
;
Xiao YANG
1
;
Qiang LYU
1
Author Information
1. Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
- Publication Type:Journal Article
- Keywords:
bladder cancer;
magnetic resonance imaging;
apparent diffusion coefficient;
ErbB receptors;
molecular targeted therapy
- From:
Journal of Modern Urology
2023;28(6):464-468
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To predict the expression of human epidermal growth factor receptor 2 (HER2) in urothelial bladder carcinoma based on normalized apparent diffusion coefficient (ADC). 【Methods】 The preoperative pelvic 3.0T magnetic resonance imaging (MRI) images of 127 patients with urothelial bladder carcinoma were retrospectively studied, the ADC was measured, and the HER2 expression in postoperative tissue specimens was determined with immunohistochemistry (IHC). The differences in normalized ADC were analyzed among different HER2 expressions and among different expression divisions. Correlation between normalized ADC and HER2 expression was analyzed. The optimal diagnostic threshold for distinguishing different expression divisions were determined with receiver operating characteristic (ROC) curve. 【Results】 Normalized ADC was negatively correlated with HER2 expression (tau-b=-0.180, P=0.008). Normalized ADC of HER2 overexpression group (IHC 2+, 3+) was lower than that of HER2 negative group (IHC 0, 1+) (P=0.081). Normalized ADC of HER2 expression group (IHC 1+, 2+, 3+) was significantly lower than that of HER2 zero-expression group (IHC 0) (P=0.020). Normalized ADC of HER2 strong positive group (IHC 3+) was significantly lower than that of HER2 non-strong positive group (IHC 0, 1+, 2+) (P=0.024). The optimal diagnostic threshold of HER2 strong positive group was 0.849; the sensitivity, specificity and accuracy were 0.621, 0.909 and 0.765, respectively. The optimal diagnostic threshold of HER2 overexpression group was 0.909; the sensitivity, specificity and accuracy were 0.547, 0.667 and 0.607, respectively. 【Conclusion】 Normalized ADC is negatively correlated with HER2 expression. ADC may be a potential marker for predicting HER2 expression.
