Advances in the study of the m6A methyltransferase METTL3 promoting bladder cancer progression via AFF4/NF-κB/MYC signaling network

VernacularTitle:m6A甲基转移酶METTL3通过AFF4/NF-κB/MYC信号网络影响膀胱癌的研究进展
Author: Mengmeng LI ^{1
,

2} ; Jinze LI ¹ ; Yin HUANG ¹ ; Bo CHEN ¹ ; Zeyu CHEN ¹ ; Liangren LIU ¹ ; Jianzhong AI ¹ ; Lu YANG ¹ ; Qiang WEI ¹ ; Dehong CAO ¹
Author Information

1. Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China
2. , West China Medical College, Sichuan University, Chengdu 610041, China
Publication Type:Journal Article
Keywords: bladder cancer; m6A; METTL3; AFF4; NF-κB; MYC
From: Journal of Modern Urology 2023;28(7):635-639
CountryChina
Language:Chinese
Abstract: Bladder cancer (BCa) is one of the most common cancers in urology,whose pathogenesis is still unclear. Methyltransferase-like 3(METTL3) is the most important part of N6-methyladenosine methyltransferase complex (m6A MTC),which mediates the methylation of mRNA to regulate the stability and translation process of mRNA. Researches have shown that METTL3 can promote BCa development via AFF4/NF-κB/MYC signaling network,which involves many kinds of signaling molecules. In addition,METTL3 can affect the expressions of AFF4,NF-κB and MYC,so as to affect their downstream signaling pathways and finally promote the malignant progression of tumor.