Expressions and clinical significance of ZEB1, AR, E-Ca and N-Ca in prostate cancer
10.3969/j.issn.1009-8291.2023.07.017
- VernacularTitle:ZEB1、AR、E-Cadherin和N-Cadherin在前列腺癌组织中的表达及意义
- Author:
Yichen GUO
1
;
Weiping LI
2
;
Ruiting YANG
1
;
Yongyou LUO
1
;
Bin LIU
1
;
Yingchun MA
1
;
Puzhong JI
1
Author Information
1. Department of Pathology, The 940th Hospital of Joint Logistics Support force of Chinese People’s Liberation Army Joint, Lanzhou 730050
2. Department of Urology, The First Hospital of Lanzhou University, Lanzhou 730030, China
- Publication Type:Journal Article
- Keywords:
prostate cancer;
epithelial-mesenchymal transformation;
ZEB1;
androgen receptor;
castration-resistant prostate cancer
- From:
Journal of Modern Urology
2023;28(7):627-631
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To analyze the correlation between the expressions of ZEB1, androgen receptor (AR), E-cadherin (E-Ca), N-cadherin (N-Ca) and clinicopathological features of prostate cancer patients with different risk levels, and to explore their significance. 【Methods】 The clinical data of 47 patients with prostate cancer treated during Nov.2013 and Jun.2021 were retrospectively analzyed. The patients were divided into medium-low risk group and high-risk group. The expressions of ZEB1, AR, E-Ca and N-Ca in the prostate cancer tissues of the two groups were detected with immunohistochemical staining. The relationship between the expressions and Gleason grade, prostate-specific antigen (PSA) level and TNM stage was analyzed. 【Results】 The positive expression rate of ZEB1 increased with higher risk, Gleason score, and PSA level (P<0.01); the strong positive expression rate of AR decreased with higher risk and Gleason score (P<0.05); the positive expression rate of E-Ca decreased with increased risk, Gleason score, and PSA level (P<0.05); the positive expression rate of N-Ca increased with the increased risk and Gleason score (P<0.01); the positive expression rate of ZEB1 increased with higher tumor stage and TNM stage (all P<0.01); the strong positive expression rate of AR decreased only with increased TNM stage (P<0.05). Patients whose first surgical specimen showing a higher expression level of ZEB1 were more likely to develop into castration-resistant prostate cancer CRPC (P<0.05). 【Conclusion】 ZEB1 and N-Ca levels increase with increased tumor aggressiveness, while AR and E-Ca levels decrease. ZEB1, AR, E-Ca and N-Ca play important roles in prostate cancer progression. ZEB1 can not only affect prostate cancer through epithelial stromal transformation (EMT), but also through AR. ZEB1 may also be related to the development of CRPC.
