A clinical study of different doses and frequencies of Sildenafil in the treatment of erectile dysfunction
10.3969/j.issn.1009-8291.2023.07.013
- VernacularTitle:不同剂量、频次枸橼酸西地那非治疗勃起功能障碍患者的疗效观察
- Author:
Xiaogang YANG
1
;
Zhiqiang WU
1
;
Huashan TIAN
1
;
Cheng CHENG
1
;
Yaping ZHOU
2
;
Yawen ZHOU
1
;
Baowei MENG
1
;
Xinlong MA
1
;
Zhilong DONG
3
Author Information
1. Department of Adult Surgery, Gansu Provincial Maternity and Child-care Hospital, Lanzhou 730050
2. Department of Surgery, The First Hospital of Lanzhou University, Lanzhou 730030
3. Department of Urology, The Second Hospital of Lanzhou University, Lanzhou 730030, China
- Publication Type:Journal Article
- Keywords:
sildenafil;
erectile dysfunction;
phosphodiesterase-5 inhibitor;
doses;
frequencies;
IIEF-5;
EHS;
SEP2/3
- From:
Journal of Modern Urology
2023;28(7):608-612
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To evaluate the efficacy and safety of different doses and frequencies of oral Sildenafil in the treatment of erectile dysfunction (ED). 【Methods】 The randomized,open clinical trial included 120 ED patients who met the inclusion and exclusion criteria. The patients were randomly divided into the following groups:on-schedule (25 mg/day),on-demand (50 mg,taken irregularly half an hour before each sexual life),new regular group (25 mg/day,50 mg more before each sexual life),regular group (100 mg/time,twice/week). All treatments lasted for 8 weeks. The follow-up indexes included the five-item International Index of Erectile Function (IIEF-5),Erection Hardness Scale (EHS) and Sexual Encounter Profile (SEP2/3). The adverse reactions were recorded. 【Results】 The IIEF-5 scores of the four groups were significantly higher than those after baseline treatment (P<0.001),but there was no significant difference among the four groups (P>0.05). In terms of effective rate,at the 16th week,there were significant differences between the on-demand group (10.7%) and new regular group (62.1%),and between the on-demand group (10.7%) and regular group (50.0%) (P<0.001). In terms of EHS, the percentage of grade 4 patients in regular group was significant higher than that in the on-demand group at the 8th week and 16th week (all P<0.05). In terms of positive rate of SEP-3,there was a significant difference between the on-demand group and regular group (P=0.042) at the 16th week. In the course of treatment,there were transient adverse reactions such as headache,blurred vision,stuffy nose and back pain,which did not affect the treatment. 【Conclusion】 All of the four treatment methods of oral sildenafil showed good efficacy. Both regular group and new regular group maintained good clinical efficacy during the follow-up,which is better than that of the on-demand group. The new regular scheme can be used as a new,safe and effective treatment option.
