Effects of status of lymph vascular invasion on the survival of patients with squamous cell carcinoma of the penis
10.3969/j.issn.1009-8291.2023.07.011
- VernacularTitle:淋巴管浸润状态对阴茎鳞状细胞癌患者生存预后的影响
- Author:
Minglin LI
1
;
Zhonghai REN
2
;
Huili MA
2
;
Xinyue MEI
2
;
Yueshi HU
1
;
Lixin YANG
1
Author Information
1. Department of Urology, Nanyang Central Hospital, Nanyang 473000, China
2. Department of Oncology, Nanyang Central Hospital, Nanyang 473000, China
- Publication Type:Journal Article
- Keywords:
carcinoma of the penis;
prognosis;
survival analysis;
risk factor;
lymph vascular invasion
- From:
Journal of Modern Urology
2023;28(7):597-602
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To explore the effects of status of lymph vascular invasion (LVI) on the survival of patients with squamous cell carcinoma of the penis (SCCP). 【Methods】 Data of patients diagnosed as SCCP during Jan.1, 2010 and Dec.31, 2019 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Kaplan-Meier method was used to draw the survival curve of patients with different LVI statuses, and log-rank test was conducted in parallel. Univariate and multivariate Cox regression analyses were used to assess the effects of LVI status on the overall survival. Patients were divided into different subgroups based on stage (localized, regional, and distant metastasis) and grade (well, moderately and poorly differentiated) of tumor, and the effects of LVI status on the overall survival of patients in different subgroups were assessed. 【Results】 A total of 1 435 patients were involved, including 1 102 (76.8%) without LVI and 333 (23.2%) with LVI. Median survival time of patients without LVI and with LVI were 27.5 months and 17.0 months, respectively (χ2=55.028, P<0.001). Cox regression analyses showed LVI was a significant prognostic factor in SCCP patients (HR=1.280, 95%CI:1.044-1.569, P=0.018). In the subgroup analysis, LVI was an independent risk factor affecting the overall survival of patients with localized tumor (HR=1.446, 95%CI:1.009-2.110, P=0.046) and regional tumor (HR=1.323, 95%CI:1.018-1.720, P=0.036);it was also an independent risk factor affecting the overall survival of SCCP patients with well differentiated tumor (HR=2.797, 95%CI:1.573-4.971, P=0.046) and moderately differentiated tumor (HR=1.431, 95%CI:1.071-1.914, P=0.015). 【Conclusion】 LVI status is a significant factor affecting the prognosis of SCCP patients. LVI is an independent risk factor for the overall survival of SCCP patients with localized and regional tumor, moderately differentiated and well differentiated tumor.
