Advances in urinary tract and intestinal microbiome related to bladder cancer
10.3969/j.issn.1009-8291.2023.09.018
- VernacularTitle:膀胱癌相关泌尿道及肠道微生物组学的研究进展
- Author:
Tianyu QI
1
;
Tao LI
1
;
Kaijie WU
1
Author Information
1. Department of Urology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
- Publication Type:Journal Article
- Keywords:
bladder cancer;
microbiome;
urinary tract flora;
intestinal flora;
tumor immunotherapy
- From:
Journal of Modern Urology
2023;28(9):818-821
- CountryChina
- Language:Chinese
-
Abstract:
Bladder cancer is one of the most common urinary tumors, and human urinary tract has been proved to be non-sterile. The significance of urinary tract flora in pathophysiology and treatment of urothelial carcinoma remains to be studied. Meanwhile, intestinal flora has also become an important clinical factor, which has been proved to play a variety of roles in body metabolism, local and systemic inflammation and immunity. Microorganisms can affect the clinical course of cancer, efficacy of chemotherapy and immunotherapy drugs, bioavailability and side effects. This review will explore the relationship between bladder cancer and urinary tract and intestinal microbiome, and explore reliable disease predictors, prognostic indicators and therapeutic targets through a better understanding of the interaction between the microbiome and tumor cells.
