Analysis of the clinical efficacy and safety of laparoscopic radical prostatectomy in prostate cancer patients aged 80 years or older
10.3969/j.issn.1009-8291.2023.09.009
- VernacularTitle:≥80岁前列腺癌患者行腹腔镜前列腺癌根治术的临床疗效及安全性
- Author:
Yang LI
1
;
Yuqing ZHANG
1
;
Kai FANG
1
;
Shengjie LIANG
1
;
Dong LIU
1
;
Min GONG
1
;
Rujian ZHU
1
Author Information
1. Department of Urology, Pudong Hospital, Fudan University, Shanghai 201399, China
- Publication Type:Journal Article
- Keywords:
prostate cancer;
laparoscopic radical prostatectomy;
80 years or older;
International Prostate Symptom Score;
total prostate specific antigen
- From:
Journal of Modern Urology
2023;28(9):775-779
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the clinical efficacy and safety of laparoscopic radical prostatectomy in elderly prostate cancer patients aged ≥80 years in good health. 【Methods】 A total of 18 octogenarian patients who underwent laparoscopic radical prostatectomy during Aug.2016 and Mar.2020 at our hospital were selected for retrospective analysis. 【Results】 The patients were 80 to 86 years old. The preoperative serum PSA was 5.25-101.00 ng/mL. There were 2 cases in stage cT1N0M0,12 in stagec T2N0M0 and 4 in stage cT3N0M. The Gleason score was ≤6 in 4 cases,=7 in 9 cases,and ≥8 in 5 cases. During the follow-up of 22 to 65 months,the rates of urinary incontinence at 1 month,3 months,6 months,and 1 year were 50.00% (9/18),33.33% (6/18),16.67% (3/18) and 5.56 %(1/18),respectively. The postoperative urinary control recovery time was 1 to 220 days. Positive incision margin developed in 3 cases and biochemical recurrence occurred in 3 cases. The IPSS score at 3, 6 months and 1 year after surgery were lower than these before surgery (P<0.05). The overall health score of the FACD-P scale at 6 months after surgery was higher than that before surgery (P<0.05). 【Conclusion】 For well selected octogenarian prostate cancer patients in good condition,laparoscopic radical prostatectomy is a feasible,safe and effective treatment option,but long-term follow-up and prospective clinical studies with large sample size are still needed to confirm its efficacy.
