Research progress on the genetic etiology and treatment of nonobstructive azoospermia
10.3969/j.issn.1009-8291.2023.10.018
- VernacularTitle:非梗阻性无精子症的遗传学病因及治疗研究进展
- Author:
Jinlong XIE
1
Author Information
1. Center of Reproductive Medicine, Weifang People’s Hospital, Weifang 261000, China
- Publication Type:Journal Article
- Keywords:
nonobstructive azoospermia;
genetic etiology;
hormonal optimization therapy;
spermatogenic microenvironment;
stem cell therapy;
microdissection testicular sperm extraction
- From:
Journal of Modern Urology
2023;28(10):911-915
- CountryChina
- Language:Chinese
-
Abstract:
Nonobstructive azoospermia (NOA) is a disease with complex etiology, genetic heterogeneity and phenotypic heterogeneity caused by multiple factors, including chromosome abnormalities, Y chromosome microdeletions, gene mutations and epigenetic modifications. At present, there is no unified and effective treatment strategy to restore spermatogenesis. The current treatment options include preoperative hormone optimization therapy, changing the testicular spermatogenesis microenvironment, and stem cell therapy. This article reviews the existing genetic etiology of NOA and related treatment methods, in order to provide reference for the clinical treatment.
