Effects of paternal age on pregnancy outcomes in frozen-thaw embryo transfer cycles
10.3969/j.issn.1009-8291.2023.10.003
- VernacularTitle:男性年龄对冻融胚胎移植周期妊娠结局的影响
- Author:
Qiao ZHOU
1
;
Hui JI
1
;
Wei JIANG
1
;
Song ZHANG
1
;
Dehong LI
1
;
Xiufeng LING
1
;
Xiaoning CHEN
1
Author Information
1. Center of Reproduction Medicine, Nanjing Maternal and Child Health Care Hospital Affiliated to Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing 210004, China
- Publication Type:Journal Article
- Keywords:
advanced paternal age;
frozen-thaw embryo transfer;
clinical pregnancy rate;
live birth rate
- From:
Journal of Modern Urology
2023;28(10):835-837
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To observe the effects of paternal age on the pregnancy outcomes in frozen embryo transfer (FET) cycles. 【Methods】 The clinical data of two groups after propensity score matching (PSM) were retrospectively analyzed, including 738 cycles in the <40 year group and 387 cycles in the 40-60 year group. The differences in general information and pregnancy outcomes were compared between the two groups, and logistic regression analysis of pregnancy outcomes were conducted. 【Results】 There were no statistical differences in age, duration of infertility, female body mass index (BMI), infertility factors, fertilization method, endometrial preparation methods, endometrial thickness on the day of transformation, stage of embryo transfer, number of embryos transferred, and number of high-quality embryos between the two groups after PSM (P>0.05). The clinical pregnancy rate (52.2%vs. 67.2%) and live birth rate (41.1% vs. 57.2%) decreased in the 40-60 year group compared with those in the <40 year group (P<0.001), but there was no statistical difference in abortion rate (19.8% vs. 13.7%) (P>0.05). 【Conclusion】 Advanced paternal age decreases clinical pregnancy rate and live birth rate.
