High preoperative neutrophile-lymphocyte ratio predicts poor prognosis of patients undergoing radical cystectomy for nonurothelial carcinoma of the bladder
10.3969/j.issn.1009-8291.2023.11.010
- VernacularTitle:术前高中性粒细胞与淋巴细胞比值预示膀胱非尿路上皮癌患者根治术后预后不良
- Author:
Shuai LIU
1
;
Xiaozhou ZHOU
1
;
Guangjie DUAN
2
;
Yuan LIU
1
;
Peng HE
1
;
Lang LANG
1
;
Zhiwen CHEN
1
Author Information
1. Department of Urology, The First Affiliated Hospital of Army Medical University, Chongqing 400042, China
2. Department of Pathology, The First Affiliated Hospital of Army Medical University, Chongqing 400042, China
- Publication Type:Journal Article
- Keywords:
nonurothelial carcinoma;
radical cystectomy;
neutrophile-lymphocyte ratio;
cancer specific survival;
overall survival
- From:
Journal of Modern Urology
2023;28(11):964-969
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the predictive value of high preoperative neutrophile-lymphocyte ratio (NLR) for the prognosis of nonurothelial carcinoma of the bladder (NUBC) after radical cystectomy (RC). 【Methods】 Clinical and follow-up data of NUBC patients undergoing RC during Jan.2005 and Dec.2020 were collected. The optimal cut-off value of NLR was determined with the receiver operating characteristic (ROC) curve. The survival curve was drawn with Kaplan-Meier method to compare the differences in cancer specific survival (CSS) and overall survival (OS) between the high-NLR and low-NLR groups. The independent risk factors of CSS and OS were screened with Cox proportional hazard regression model. 【Results】 Of the 62 eligible cases,34 (54.8%) were diagnosed with adenocarcinoma,17 (27.4%) with squamous cell carcinoma, 6 (9.7%) with small cell carcinoma and 5 (8.1%) with sarcoma. Kaplan-Meier analysis results showed high NLR was associated with poor CSS (P=0.001) and OS (P<0.001). Cox regression results indicated that high NLR (HR=2.42, 95%CI: 1.12-5.23, P=0.025) and advanced pathologic tumor stage (HR=3.21, 95%CI:1.53-6.74,P=0.002) were independent risk factors of unfavorable CSS. Similarly, high NLR (HR=2.75, 95%CI: 1.35-5.56, P=0.005) and advanced pathologic tumor stage (HR=2.81, 95%CI:1.43-5.57, P=0.003) were independent risk factors of unfavorable OS. 【Conclusion】 As an independent risk factor of unfavorable CSS and OS in NUBC patients undergoing RC, high preoperative NLR is of great value in the prediction of long-term prognosis and may help to optimize individualized treatment.
