Effects of preoperative lipid metabolism indexes on the prognosis of patients with non-muscular invasive bladder cancer
10.3969/j.issn.1009-8291.2023.11.009
- VernacularTitle:使用术前脂质代谢指标预测非肌层浸润性膀胱癌患者术后预后的效用
- Author:
Haibin ZHOU
1
;
Li XUE
1
;
Hang BI
1
;
Zihe PENG
1
;
Yao DONG
1
;
Tie CHONG
1
Author Information
1. Department of Urology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China
- Publication Type:Journal Article
- Keywords:
lipid metabolism indicators;
high-density lipoprotein;
non-muscular invasive bladder cancer;
recurrence risk prediction model;
bloodlipid
- From:
Journal of Modern Urology
2023;28(11):957-963
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the effects of preoperative lipid metabolism level on the postoperative prognosis of non-muscular invasive bladder cancer (NMIBC). 【Methods】 Clinical data of NMIBC patients who underwent surgical treatment in our hospital during Mar.2014 and May 2021 were retrospectively analyzed. Based on receiver operating characteristic (ROC) curve, the optimal cutoff values of all lipid metabolism indicators were determined and patients were classified accordingly. The independent risk factors for postoperative recurrence were identified with Cox regression model. The survival was analyzed with Kaplan-Meier, and recurrence-free survival (RFS) was compared using log-rank tests. A recurrence risk prediction model was established based on the high-density lipoprotein (HDL) and other clinic pathological factors and the accuracy of prediction was evaluated with the area under the ROC curve (AUC). 【Results】 Cox multivariate analysis showed HDL, tumor number, tumor size and histological grade were independent risk factors for recurrence (P<0.05). Kaplan-Meier analysis showed that RFS was significantly longer in the high-HDL group than in the low-HDL group (P<0.001). Incorporating HDL, tumor number, tumor size, histological grade, and tumor stage into the recurrence risk model, the AUC was 0.706, and internal cross validation showed the AUC was 0.711. 【Conclusion】 Preoperative HDL is an independent risk factor affecting the RFS of patients with NMIBC, and combining it with clinic pathological factors will improve the prediction of tumor recurrence.
